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• W2039483889 abstract "Tissue AntigensVolume 34, Issue 1 p. 39-49 Molecular basis and functional importance of some disease-associated HLA polymorphisms E. Thorsby, Corresponding Author E. Thorsby Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwayProf. E. Thorsby Institute of Transplantation Immunology Rikshospitalet The National Hospital 0027 Oslo 1 NorwaySearch for more papers by this authorK. E. A. Lundin, K. E. A. Lundin Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this authorK. S. Rønningen, K. S. Rønningen Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this authorL. M. Sollid, L. M. Sollid Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this authorF. Vartdal, F. Vartdal Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this author E. Thorsby, Corresponding Author E. Thorsby Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwayProf. E. Thorsby Institute of Transplantation Immunology Rikshospitalet The National Hospital 0027 Oslo 1 NorwaySearch for more papers by this authorK. E. A. Lundin, K. E. A. Lundin Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this authorK. S. Rønningen, K. S. Rønningen Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this authorL. M. Sollid, L. M. Sollid Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this authorF. Vartdal, F. Vartdal Institute of Transplantation Immunology, Rikshospitalet, The National Hospital, Oslo, NorwaySearch for more papers by this author First published: July 1989 https://doi.org/10.1111/j.1399-0039.1989.tb01716.xCitations: 8AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References Aparacio, J. M. R., Wakisaka, A., Takada, A., Matsuura, N. & Aizawa, M. (1988) HLA-DQ system and insulin-dependent mellitus Japanese: does it contribute to the development of IDDM as it does in Caucasians Immunogenetics 23, 240– 246. Bertrams, J. & Baur, M. P. (1984) Insulin-dependent diabetes mellitus. In Histocompatibility Testing 1984, pp. 348– 358, Springer-Verlag, Berlin . Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L. & Wiley, D. C. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329, 506– 518. Bottazzo, G. F., Todd, I., Mirakian, R., Belfiore, A. & Pujol-Borrell, R. (1986) Organ-specific autoimmunity: a 1986 overview. Immunol Rev 94, 137– 169. Brown, J. H., Jardetzky, T., Saper, M. A., Samraoui, B., Bjorkman, P. J. & Wiley, D. C. (1988) A hypothetical model of the foreign antigen binding site of Class II histocompatibility molecules. Nature 332, 845– 850. Burakoff, S. J., Finberg, R., Glimcher, L., Lemonnier, F., Benacerraf, B. & Cantor, H. (1978) The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens. J Exp Med 148, 1414– 1422. Calder, V., Owen, S., Watson, C., Feldmano, M. & Davison, A. (July 1989) MS: a localized immune disease of the central nervous system. Immunology Today 10, 99– 103. Compston, A. (1986) Genetic factors in the aetiology of multiple sclerosis. In Multiple Sclerosis, Butterworths, London . Cohen-Haguenauer, O., Robbins, E., Busson, M., Deschamps, I., Hors, J., Lalouel, J. M., Dausset, J. & Cohen, D. (1985) A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus. Proc Natl Acad Sci USA 82, 3335– 3339. Horn, G. T., Bugawan, T. L., Long, M. C. & Erlich, H. A. (1988) Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility. Proc Natl Acad Sci USA 115, 6012– 6016. Howell, M. D., Smith, J. R., Austin, R. K., Kelleher, D., Nepom, G. T., Volk, B. & Kagnoff, M. F. (1988) An extended HLA-D region haplotype associated with celiac disease. Proc Natl Acad Sci USA 85, 222– 226. Knowles, R. W. (July 1989) Assignment of HLA-class II α and β chain 2-D gel patterns for the Workshop reference panel of B lymphoblastoid cell lines. In Immunobiology of HLA, Springer-Verlag, New York (in press). Kourilsky, P. & Claverie, J. M. (July 1989) MHT restriction, alloreactivity, and thymic education: a common link Cell 56, 327– 329. Lemonnier, F., Burakoff, S., Germain, R. N. & Benacerraf, B. (1977) Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells. Proc Nail Acad Sci USA 74, 1229– 1233. Lundin, K. E. A., Gaudernack, G., Qvigstad, E., Sollid, L. M. & Thorsby, E. (1988) T lymphocyte clones recognizing an HLA-DQw33.2-associated epitope involving residue 57 on the DQβ chain. Hum Immunol 22, 235– 246. Lundin, K. E. A., Rønningen, K. S., Aono, S., Spurkland, A., Gaudernack, G., Isshiki, G. & Thorsby, E. (July 1989) HLA-DQ antigens of Japanese IDDM patients. (Submitted for publication). Matzinger, P. & Bevan, M. J. (1977) Hypothesis. Why do so many lymphocytes respond to major histocompatibility antigens Cell Immunol 29, 1– 5. Mearin, M. L., Biemond, I., Pena, A. S., Polanco, I., Vasquez, G., Schreuder, Th. M., de Vries, R. R. P. & van Rood, J. J. (1983) HLA-DR phenotypes in Spanish coeliac children; their contribution to the understanding of the genetics of the disease. Gut 24, 532– 537. Morel, P. A., Dorman, J. S., Todd, J. A., McDervitt, H. O. & Trucco, M. (1988) Aspartic acid at position 57 of the HLA-DQβ chain protects against type I diabetes: a family study. Proc Natl Acad Sci USA 85, 8111– 8115. Morellini, M., Trabace, S., Mazzilli, M. C., Lulli, P., Capellacci, S., Bonamico, M., Margarit, I. & Gandini, E. (1988) A Study Of HLA class II antigens in an Italian paediatric population with coeliac disease. Disease Markers 6, 23– 28. Nepom, B. S., Palmer, J., Kim, S. J., Hansen, J. A., Holbeck, S. L. & Nepom, G. T. (1986) Specific genomic markers for the HLA-DQ subregion discriminate between DR4+ insulin-dependent diabetes mellitus and DR4+ seropositive juvenile rheumatoid arthritis. J Exp Med 164, 345– 350. Niven, M. J., Caffrey, C., Sachs, J. A., Cassell, P. G., Gallagher, R. B., Kumar, P. & Hitman, G. A. (1987) Susceptibility to coeliac disease involves genes in HLA-DP region. Lancet ii, 805. Owerbach, D., Lernmark, Ǎ., Platz, P., Ryder, L. P., Rask, L., Peterson, P. A. & Ludvigsson, J. (1983) HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individuals. Nature 303, 815– 817. Rønniogen, K. S., Markussen, G., Iwe, Th. & Thorsby, E. (1989a) An increased risk of insulin-dependent diabetes mellitus (IDDM) among HLA-DR4, DQw8/DRw8, DQw4 heterozygotes. Hum Immunol 24, 165– 173. Rønningen, K. S., Iwe, Th., Halstensen, T. S., Spurkland, A. & Thorsby, E. (1989b) The amino acid at position 57 of the HLA-DQβ chain and susceptibility to develop insulin-dependent diabetes mellitus. Hum Immunol (in press). Rossini, A. A., Mordes, J. P. & Like, A. A. (1985) Immunology of insulin-dependent diabetes mellitus. Am Rev Immunol 3, 289– 320. Sollid, L. M., Markussen, G., Ek, J., Gjerde, H., Vartdal, V. & Thorsby, E. (July 1989) Evidence for a primary association of celiac disease to a particular HLA-DQ α/β heterodimer. J Exp Med 169, 345– 350. Svejgaard, A., Platz, P. & Ryder, L. P. (1983) HLA and disease 1982 — a survey. Immunol Rev 70, 193– 218. Thompson, G. (1984) HLA DR antigens and susceptibility to insulin-dependent diabetes mellitus. Am J Hum Genet 36, 1309– 1317. Tiwari, J. L. & Terasaki, P. I. (1985) HLA and Disease Associations. Springer-Verlag. New York . Todd, J. A., Bell, J. I. & McDevitt, H. O. (1987) HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329, 599– 604. Tosi, R., Tanigaki, N., Polanco, I., DeMarchi, M., Woodrow, J. C. & Hetzel, P. A. (1986) A radioimmunoassay typing study of non-DQw2-associated celiac disease. Clin Immunol Immunopathol 39, 168– 172. Vartdal, F., Sollid, L. M., Vandvik, B., Markussen, G. & Thorsby, E. (July 1989) Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic aminoacid-sequences. Hum Immunol 25, 103– 110. Werdelin, O. (1987) T cells recognize antigen alone and not MHC molecules. Immunology Today 8, 80– 84. Citing Literature Volume34, Issue1July 1989Pages 39-49 ReferencesRelatedInformation" @default.
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