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- W2039492746 abstract "The purpose of this study was to examine telomerase activity and apoptotic changes in HeLa cells persistently infected with influenza viruses B/Lee/40 (He/Le cells).He/Le cells were established as described previously [Intervirology 2002;45:67-70], and passaged twice a week. The existence of influenza virus genes was monitored by the reverse transcription polymerase chain reaction (RT-PCR). Telomerase activities in He/Le cells were assayed by Telochaser (stretch PCR method). Apoptotic changes in He/Le cells were examined using the Apoptotic DNA Ladder Kit and the In situ Cell Death Detection Kit, Fluorescence.In He/Le cells, (1) all eight influenza virus genes were detected by RT-PCR until 62 days post infection (p.i.); (2) only nucleoprotein gene remained detectable until 120 days p.i.; (3) telomerase activity of He/Le cells normalized to those of uninfected HeLa cells was remarkably decreased (16-55% of control) during the persistence of influenza and recovered up to 80% of control on day 168 p.i. when no influenza virus gene was detected by RT-PCR, and (4) no apoptotic changes were detected despite the continuous existence of influenza virus genes.In He/Le cells, telomerase activity was suppressed exclusively during the persistence of influenza, and no apoptotic changes were detected." @default.
- W2039492746 created "2016-06-24" @default.
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- W2039492746 date "2003-01-01" @default.
- W2039492746 modified "2023-09-25" @default.
- W2039492746 title "Characterization of HeLa Cells Persistently Infected with Influenza Virus B/Lee/40 with Respect to Telomerase Activity and Apoptosis" @default.
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- W2039492746 doi "https://doi.org/10.1159/000073211" @default.
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