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- W2039508724 abstract "Summary. Phenotypic switching in Candida albicans is a reversible, high‐frequency phenomenon that is readily detectable in a fungal population as changes in cell or colony morphology. Some putative attributes of virulence in C. albicans , including expression of cell wall glycoproteins, secretion of proteolytic enzymes and hypha formation have been associated with switching phenomena. C. albicans isolates from active infection tend to show a higher prevalence of phenotypic switching than those associated with commensalism. Moreover, some characteristics of azole resistance in C. albicans are compatible with a switch of phenotype. There is thus a preliminary basis of scientific evidence for a hypothesis that phenotypic switching may indeed serve as an attribute of virulence in at least one pathogenic fungus, facilitating invasion and escape from host defences. Zusammenfassung. Der Phänotypwechsel von Candida albicans ist ein reversibles, häufiges Phänomen, das in einer Pilzpopulation als Änderung der Zell‐ oder Koloniemorphologie leicht erkennbar ist. Einige wahr‐scheinliche Virulenzeigenschaften von C. albicans , wie die Bildung von Zellwand‐Glykoproteinen, die Sekretion proteolytischer Enzyme und die Hyphenbildung, sind mit Phänotypwechsel in Zusammenhang gebracht worden. C. albicans ‐Isolate aus aktiven Infektionen zeigen eine höhere Phänotypwechsel‐Prävalenz als Isolate aus kommensalen Populationen. Darüber hinaus sind auch einige Besonderheiten der Azolresistenz von C. albicans an Phänotypwechsel gebunden. Die Hypothese, daß Phänotypwechsel als Virulenzattribut anzusehen ist, gewinnt daher zumindest in einer pathogenen Pilz‐art an Wahrscheinlichkeit, Eigenschaften, welche die Invasion des Pilzes und das Ausweichen vor Wirtsabwehrreaktionen erleichtern." @default.
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- W2039508724 date "1997-10-01" @default.
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- W2039508724 title "Switch of phenotype as an escape mechanism of the intruder" @default.
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- W2039508724 doi "https://doi.org/10.1111/j.1439-0507.1997.tb00556.x" @default.
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