Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039510157> ?p ?o ?g. }
- W2039510157 endingPage "273" @default.
- W2039510157 startingPage "263" @default.
- W2039510157 abstract "Synthesized in the cytosol of cells, a fraction of cytosolic glutathione (GSH) is then transported into the mitochondrial matrix where it reaches a high concentration and plays a critical role in defending mitochondria against oxidants and electrophiles. Evidence mainly from kidney and liver mitochondria indicated that the dicarboxylate and the 2-oxoglutarate carriers contribute to the transport of GSH across the mitochondrial inner membrane. However, differential features between kidney and liver mitochondrial GSH (mGSH) transport seem to suggest the existence of additional carriers the identity of which remains to be established. One of the characteristic features of the hepatic mitochondrial transport of GSH is its regulation by membrane fluidity. Conditions leading to increased cholesterol deposition in the mitochondrial inner membrane such as in alcohol-induced liver injury decrease membrane fluidity and impair the mitochondrial transport of GSH. Depletion of mitochondrial GSH by alcohol is believed to contribute to the sensitization of the liver to alcohol-induced injury through tumor necrosis factor (TNF)-mediated hepatocellular death. Through control of mitochondrial electron transport chain-generated oxidants, mitochondrial GSH modulates cell death and hence its regulation may be a key target to influence disease progression and drug-induced cell death." @default.
- W2039510157 created "2016-06-24" @default.
- W2039510157 creator A5019266732 @default.
- W2039510157 creator A5043356624 @default.
- W2039510157 date "2005-05-01" @default.
- W2039510157 modified "2023-10-18" @default.
- W2039510157 title "Hepatic mitochondrial glutathione: transport and role in disease and toxicity" @default.
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