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• W2039512924 endingPage "23036" @default.
• W2039512924 startingPage "23024" @default.
• W2039512924 abstract "Helicobacter pylori CagA plays a key role in gastric carcinogenesis. Upon delivery into gastric epithelial cells, CagA binds and deregulates SHP-2 phosphatase, a bona fide oncoprotein, thereby causing sustained ERK activation and impaired focal adhesions. CagA also binds and inhibits PAR1b/MARK2, one of the four members of the PAR1 family of kinases, to elicit epithelial polarity defect. In nonpolarized gastric epithelial cells, CagA induces the hummingbird phenotype, an extremely elongated cell shape characterized by a rear retraction defect. This morphological change is dependent on CagA-deregulated SHP-2 and is thus thought to reflect the oncogenic potential of CagA. In this study, we investigated the role of the PAR1 family of kinases in the hummingbird phenotype. We found that CagA binds not only PAR1b but also other PAR1 isoforms, with order of strength as follows: PAR1b > PAR1d >or= PAR1a > PAR1c. Binding of CagA with PAR1 isoforms inhibits the kinase activity. This abolishes the ability of PAR1 to destabilize microtubules and thereby promotes disassembly of focal adhesions, which contributes to the hummingbird phenotype. Consistently, PAR1 knockdown potentiates induction of the hummingbird phenotype by CagA. The morphogenetic activity of CagA was also found to be augmented through inhibition of non-muscle myosin II. Because myosin II is functionally associated with PAR1, perturbation of PAR1-regulated myosin II by CagA may underlie the defect of rear retraction in the hummingbird phenotype. Our findings reveal that CagA systemically inhibits PAR1 family kinases and indicate that malfunctioning of microtubules and myosin II by CagA-mediated PAR1 inhibition cooperates with deregulated SHP-2 in the morphogenetic activity of CagA." @default.
• W2039512924 created "2016-06-24" @default.
• W2039512924 creator A5003282606 @default.
• W2039512924 creator A5051841787 @default.
• W2039512924 creator A5061468745 @default.
• W2039512924 creator A5074335831 @default.
• W2039512924 date "2009-08-01" @default.
• W2039512924 modified "2023-10-17" @default.
• W2039512924 title "Role of Partitioning-defective 1/Microtubule Affinity-regulating Kinases in the Morphogenetic Activity of Helicobacter pylori CagA" @default.
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• W2039512924 doi "https://doi.org/10.1074/jbc.m109.001008" @default.
• W2039512924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2755709" @default.
• W2039512924 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19553659" @default.
• W2039512924 hasPublicationYear "2009" @default.
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