Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039514730> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2039514730 endingPage "143" @default.
- W2039514730 startingPage "138" @default.
- W2039514730 abstract "Radioisotopic methods for the determination of the glomerular filtration rate (GFR) are highly accurate but require the collection of multiple blood and urine samples and are costly to perform due to personnel, material, and analysis costs. Nonradioactive methods of GFR determination have the potential of minimizing procedure costs while preserving accuracy. We determined the GFR simultaneously by 125I-iothalamate and nonradioactive iohexol clearance methods in 41 adults. The study group consisted of 54% males, with a mean age of 50.7 (range 28-79) years and a mean GFR by 125I-iothalamate clearance of 66.5 +/- 28.3 (range 10-118) ml/min. The iohexol concentrations were measured by a simplified high-performance liquid chromatography method that did not require sample preparation. The iohexol plasma clearance was calculated by both a new one-compartment model as well as by Jacobsson's one-compartment model. Using Jacobsson's single-sample model and data from the 240-min point, there was an excellent correlation between 125 I-iothalamate and nonradioactive iohexol clearance values: r2 = 0.95, standard error of the estimate = 11.4 ml/min, and intrapatient coefficient of variation = 16.9%. However, this formula tended to overestimate GFRs < 30 ml/min and to underestimate GFRs > 80 ml/min. The new one-compartment model is a modification of Bubeck's model, originally used for the determination of renal plasma blood flow. Using this modified model, there was an excellent correlation between 125I-iothalamate and nonradioactive iohexol clearance values at all levels of GFR tested: r2 = 0.95, standard error of the estimate = 9.2 ml/min, and intrapatient coefficient of variation = 13.7%. In conclusion, the determination of the plasma clearance of iohexol by a nonradioactive technique and a monoexponential model is a simple and accurate method of determining the GFR in patients with varying degrees of renal impairment." @default.
- W2039514730 created "2016-06-24" @default.
- W2039514730 creator A5032403473 @default.
- W2039514730 creator A5067252939 @default.
- W2039514730 creator A5080584791 @default.
- W2039514730 creator A5089940299 @default.
- W2039514730 date "1996-01-01" @default.
- W2039514730 modified "2023-09-26" @default.
- W2039514730 title "Measurement of Glomerular Filtration Rate Using Nonradioactive lohexol: Comparison of Two One-Compartment Models" @default.
- W2039514730 doi "https://doi.org/10.1159/000168985" @default.
- W2039514730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8919230" @default.
- W2039514730 hasPublicationYear "1996" @default.
- W2039514730 type Work @default.
- W2039514730 sameAs 2039514730 @default.
- W2039514730 citedByCount "34" @default.
- W2039514730 countsByYear W20395147302012 @default.
- W2039514730 countsByYear W20395147302013 @default.
- W2039514730 countsByYear W20395147302014 @default.
- W2039514730 countsByYear W20395147302016 @default.
- W2039514730 countsByYear W20395147302018 @default.
- W2039514730 crossrefType "journal-article" @default.
- W2039514730 hasAuthorship W2039514730A5032403473 @default.
- W2039514730 hasAuthorship W2039514730A5067252939 @default.
- W2039514730 hasAuthorship W2039514730A5080584791 @default.
- W2039514730 hasAuthorship W2039514730A5089940299 @default.
- W2039514730 hasConcept C111368507 @default.
- W2039514730 hasConcept C112705442 @default.
- W2039514730 hasConcept C126322002 @default.
- W2039514730 hasConcept C126894567 @default.
- W2039514730 hasConcept C127313418 @default.
- W2039514730 hasConcept C159641895 @default.
- W2039514730 hasConcept C185592680 @default.
- W2039514730 hasConcept C203635412 @default.
- W2039514730 hasConcept C2779093167 @default.
- W2039514730 hasConcept C2909957684 @default.
- W2039514730 hasConcept C2989005 @default.
- W2039514730 hasConcept C3018403923 @default.
- W2039514730 hasConcept C3018577593 @default.
- W2039514730 hasConcept C43617362 @default.
- W2039514730 hasConcept C71924100 @default.
- W2039514730 hasConcept C89838059 @default.
- W2039514730 hasConceptScore W2039514730C111368507 @default.
- W2039514730 hasConceptScore W2039514730C112705442 @default.
- W2039514730 hasConceptScore W2039514730C126322002 @default.
- W2039514730 hasConceptScore W2039514730C126894567 @default.
- W2039514730 hasConceptScore W2039514730C127313418 @default.
- W2039514730 hasConceptScore W2039514730C159641895 @default.
- W2039514730 hasConceptScore W2039514730C185592680 @default.
- W2039514730 hasConceptScore W2039514730C203635412 @default.
- W2039514730 hasConceptScore W2039514730C2779093167 @default.
- W2039514730 hasConceptScore W2039514730C2909957684 @default.
- W2039514730 hasConceptScore W2039514730C2989005 @default.
- W2039514730 hasConceptScore W2039514730C3018403923 @default.
- W2039514730 hasConceptScore W2039514730C3018577593 @default.
- W2039514730 hasConceptScore W2039514730C43617362 @default.
- W2039514730 hasConceptScore W2039514730C71924100 @default.
- W2039514730 hasConceptScore W2039514730C89838059 @default.
- W2039514730 hasIssue "2" @default.
- W2039514730 hasLocation W20395147301 @default.
- W2039514730 hasLocation W20395147302 @default.
- W2039514730 hasOpenAccess W2039514730 @default.
- W2039514730 hasPrimaryLocation W20395147301 @default.
- W2039514730 hasRelatedWork W1895721478 @default.
- W2039514730 hasRelatedWork W2010436410 @default.
- W2039514730 hasRelatedWork W2039514730 @default.
- W2039514730 hasRelatedWork W2044403730 @default.
- W2039514730 hasRelatedWork W2057599470 @default.
- W2039514730 hasRelatedWork W2060594606 @default.
- W2039514730 hasRelatedWork W2112427152 @default.
- W2039514730 hasRelatedWork W3029913735 @default.
- W2039514730 hasRelatedWork W3136324344 @default.
- W2039514730 hasRelatedWork W4293096866 @default.
- W2039514730 hasVolume "16" @default.
- W2039514730 isParatext "false" @default.
- W2039514730 isRetracted "false" @default.
- W2039514730 magId "2039514730" @default.
- W2039514730 workType "article" @default.