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- W2039520943 abstract "Abstract Purpose Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting in a lack of cortisol and aldosterone as well as an overproduction of androgens. Raised levels of androgens leads to increased mass in the laryngeal tissues thus may lower the fundamental frequency (F0) in females. Material and Methods We investigated voice characteristics in thirty-eight women with CAH and 24 control women between 18-63 years using acoustic analysis, subjective self-ratings using visual analogue scales of voice symptoms and perceptual analysis regarding dark voice timbre and pitch. Recordings were made of a standard reading passage in a sound treated booth. Acoustic analyses were made of the patient´s fundamental frequency and of min and max F0 in the habitual speech range phonetogram. This was evaluated in relation to mutation and treatment compliance. Results Women with CAH regarded the voice to be a problem in daily life more often than controls. The patient group had statistically significant lower mean fundamental frequency (MF0), as well as lower min and max F0 measured from the speech range profiles as compared to the controls. The perceptual analysis showed that the patients had significantly darker voice timbre and lower pitch than the controls. This was associated with lower treatment compliance but not to the mutation. Conclusions The patients’ voices are affected by androgens due to late diagnosis or undertreatment with cortisol. The results suggest the need for information that voice problems may occur and that referral for voice assessment may be needed." @default.
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- W2039520943 date "2008-04-01" @default.
- W2039520943 modified "2023-09-30" @default.
- W2039520943 title "Voice Characteristics Related to Increased Levels of Androgens in Women with Congenital Adrenal Hyperplasia (CAH)" @default.
- W2039520943 doi "https://doi.org/10.1016/j.jpurol.2008.01.173" @default.
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