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• W2039536466 endingPage "88" @default.
• W2039536466 startingPage "73" @default.
• W2039536466 abstract "Chronic respiratory infection is the main cause of morbidity and mortality in cystic fibrosis (CF) patients. One of the hallmarks of these infections, led by the opportunistic pathogen Pseudomonas aeruginosa, is their long-term (lifelong) persistence despite intensive antimicrobial therapy. Antimicrobial resistance in CF is indeed a multifactorial problem, which includes physiological changes, represented by the transition from the planktonic to the biofilm mode of growth and the acquisition of multiple (antibiotic resistance) adaptive mutations catalyzed by frequent mutator phenotypes. Emerging multidrug-resistant CF pathogens, transmissible epidemic strains and transferable genetic elements (such as those encoding class B carbapenemases) also significantly contribute to this concerning scenario. Strategies directed to combat biofilm growth, prevent the emergence of mutational resistance, promote the development of novel antimicrobial agents against multidrug-resistant strains and implement strict infection control measures are thus needed." @default.
• W2039536466 created "2016-06-24" @default.
• W2039536466 creator A5000378072 @default.
• W2039536466 creator A5048017496 @default.
• W2039536466 creator A5057168193 @default.
• W2039536466 creator A5085286118 @default.
• W2039536466 date "2014-12-26" @default.
• W2039536466 modified "2023-10-18" @default.
• W2039536466 title "The problems of antibiotic resistance in cystic fibrosis and solutions" @default.
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