FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039536493> ?p ?o ?g. }

• W2039536493 endingPage "4257" @default.
• W2039536493 startingPage "4257" @default.
• W2039536493 abstract "Polyethylene glycol-coated graphene oxide attenuates antigen-specific IgE production and enhanced antigen-induced T-cell reactivity in ovalbumin-sensitized BALB/c mice Hsin-Ying Wu,1,* Kun-Ju Lin,2,* Ping-Yen Wang,1 Chi-Wen Lin,3 Hong-Wei Yang,3 Chen-Chi M Ma,3 Yu-Jen Lu,4 Tong-Rong Jan1 1Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; 2Animal Molecular Imaging Center and Department of Nuclear Medicine, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan; 3Department of Chemical Engineering, National Tsing Hua University, Hsin-Chu, Taiwan; 4Department of Neurosurgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan *These authors contributed equally to this work Background: Graphene oxide (GO) is a promising nanomaterial for potential application in the versatile field of biomedicine. Graphene-based nanomaterials have been reported to modulate the functionality of immune cells in culture and to induce pulmonary inflammation in mice. Evidence pertaining to the interaction between graphene-based nanomaterials and the immune system in vivo remains scarce. The present study investigated the effect of polyethylene glycol-coated GO (PEG-GO) on antigen-specific immunity in vivo. Methods: BALB/c mice were intravenously administered with a single dose of PEG-GO (0.5 or 1 mg/kg) 1 hour before ovalbumin (OVA) sensitization, and antigen-specific antibody production and splenocyte reactivity were measured 7 days later. Results: Exposure to PEG-GO significantly attenuated the serum level of OVA-specific immunoglobulin E. The production of interferon-γ and interleukin-4 by splenocytes restimulated with OVA in culture was enhanced by treatment with PEG-GO. In addition, PEG-GO augmented the metabolic activity of splenocytes restimulated with OVA but not with the T-cell mitogen concanavalin A. Conclusion: Collectively, these results demonstrate that systemic exposure to PEG-GO modulates several aspects of antigen-specific immune responses, including the serum production of immunoglobulin E and T-cell functionality. Keywords: graphene oxide, T-cell, antigen-specific, immune, ovalbumin" @default.
• W2039536493 created "2016-06-24" @default.
• W2039536493 creator A5013491696 @default.
• W2039536493 creator A5020508750 @default.
• W2039536493 creator A5032239293 @default.
• W2039536493 creator A5048680974 @default.
• W2039536493 creator A5051815699 @default.
• W2039536493 creator A5054610562 @default.
• W2039536493 creator A5066233544 @default.
• W2039536493 creator A5082289579 @default.
• W2039536493 date "2014-09-01" @default.
• W2039536493 modified "2023-10-18" @default.
• W2039536493 title "Polyethylene glycol-coated graphene oxide attenuates antigen-specific IgE production and enhanced antigen-induced T-cell reactivity in ovalbumin-sensitized BALB/c mice" @default.
• W2039536493 cites W1912050442 @default.
• W2039536493 cites W1964097351 @default.
• W2039536493 cites W1970939551 @default.
• W2039536493 cites W1972922050 @default.
• W2039536493 cites W1976787731 @default.
• W2039536493 cites W1978656850 @default.
• W2039536493 cites W1986081303 @default.
• W2039536493 cites W1989037178 @default.
• W2039536493 cites W1992670984 @default.
• W2039536493 cites W1992993509 @default.
• W2039536493 cites W1995487267 @default.
• W2039536493 cites W2004459336 @default.
• W2039536493 cites W2010226025 @default.
• W2039536493 cites W2022394525 @default.
• W2039536493 cites W2023590633 @default.
• W2039536493 cites W2025531839 @default.
• W2039536493 cites W2027237872 @default.
• W2039536493 cites W2028464008 @default.
• W2039536493 cites W2037794305 @default.
• W2039536493 cites W2038088002 @default.
• W2039536493 cites W2048294524 @default.
• W2039536493 cites W2052024521 @default.
• W2039536493 cites W2056368730 @default.
• W2039536493 cites W2057330747 @default.
• W2039536493 cites W2058122340 @default.
• W2039536493 cites W2073208965 @default.
• W2039536493 cites W2077637800 @default.
• W2039536493 cites W2093015177 @default.
• W2039536493 cites W2113078812 @default.
• W2039536493 cites W2114918609 @default.
• W2039536493 cites W2120948675 @default.
• W2039536493 cites W2122743399 @default.
• W2039536493 cites W2126941192 @default.
• W2039536493 cites W2136459729 @default.
• W2039536493 cites W2154580307 @default.
• W2039536493 cites W2154993099 @default.
• W2039536493 cites W2165480503 @default.
• W2039536493 cites W2125203621 @default.
• W2039536493 doi "https://doi.org/10.2147/ijn.s66768" @default.
• W2039536493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4162634" @default.
• W2039536493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25228804" @default.
• W2039536493 hasPublicationYear "2014" @default.
• W2039536493 type Work @default.
• W2039536493 sameAs 2039536493 @default.
• W2039536493 citedByCount "10" @default.
• W2039536493 countsByYear W20395364932016 @default.
• W2039536493 countsByYear W20395364932018 @default.
• W2039536493 countsByYear W20395364932019 @default.
• W2039536493 countsByYear W20395364932020 @default.
• W2039536493 countsByYear W20395364932023 @default.
• W2039536493 crossrefType "journal-article" @default.
• W2039536493 hasAuthorship W2039536493A5013491696 @default.
• W2039536493 hasAuthorship W2039536493A5020508750 @default.
• W2039536493 hasAuthorship W2039536493A5032239293 @default.
• W2039536493 hasAuthorship W2039536493A5048680974 @default.
• W2039536493 hasAuthorship W2039536493A5051815699 @default.
• W2039536493 hasAuthorship W2039536493A5054610562 @default.
• W2039536493 hasAuthorship W2039536493A5066233544 @default.
• W2039536493 hasAuthorship W2039536493A5082289579 @default.
• W2039536493 hasBestOaLocation W20395364931 @default.
• W2039536493 hasConcept C141105273 @default.
• W2039536493 hasConcept C147483822 @default.
• W2039536493 hasConcept C159654299 @default.
• W2039536493 hasConcept C185592680 @default.
• W2039536493 hasConcept C189976730 @default.
• W2039536493 hasConcept C203014093 @default.
• W2039536493 hasConcept C2776529007 @default.
• W2039536493 hasConcept C2776946954 @default.
• W2039536493 hasConcept C71924100 @default.
• W2039536493 hasConcept C8891405 @default.
• W2039536493 hasConceptScore W2039536493C141105273 @default.
• W2039536493 hasConceptScore W2039536493C147483822 @default.
• W2039536493 hasConceptScore W2039536493C159654299 @default.
• W2039536493 hasConceptScore W2039536493C185592680 @default.
• W2039536493 hasConceptScore W2039536493C189976730 @default.
• W2039536493 hasConceptScore W2039536493C203014093 @default.
• W2039536493 hasConceptScore W2039536493C2776529007 @default.
• W2039536493 hasConceptScore W2039536493C2776946954 @default.
• W2039536493 hasConceptScore W2039536493C71924100 @default.
• W2039536493 hasConceptScore W2039536493C8891405 @default.
• W2039536493 hasLocation W20395364931 @default.
• W2039536493 hasLocation W20395364932 @default.
• W2039536493 hasLocation W20395364933 @default.
• W2039536493 hasLocation W20395364934 @default.
• W2039536493 hasOpenAccess W2039536493 @default.

• next