FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039547211> ?p ?o ?g. }

• W2039547211 endingPage "186" @default.
• W2039547211 startingPage "181" @default.
• W2039547211 abstract "The effects of pretreatment with protein kinase C and protein kinase A inhibitors on the intraventricular insulin-induced attenuation of the antinociceptive effect of [D-Ala2, N-MePhe4, Gly-ol5]enkephalin (DAMGO) were studied in mice. Intracerebroventricular (i.c.v.) pretreatment with insulin dose- and time-dependently attenuated the antinociceptive effect of i.c.v. DAMGO (5.6 ng) in mice. Intracerebroventricular pretreatment with a highly selective tyrosine kinase inhibitor, herbimycin A, at doses of 200 and 600 ng for 70 min, dose-dependently reversed the attenuation of the antinociceptive effect of DAMGO (5.6 ng, i.c.v.) caused by insulin. Furthermore, i.c.v. pretreatment with serine/threonin kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine hydrochloride (H7), at doses of 3-30 nmol for 60 min, dose-dependently reversed the attenuation of the antinociceptive effect of DAMGO (5.6 ng, i.c.v.) caused by insulin. Intracerebroventricular pretreatment with selective protein kinase C inhibitor, calphostin C, at doses of 1 and 3 pmol for 60 min, but not with a highly protein kinase A inhibitor, (8R, 9S, 11S)-(-)-9-hydroxy-9-n-hexyloxy-carbonyl-8-methyl-2, 3, 9, 20-tetrahydro-8, 11-epoxy-1H, 8H, 11H-2, 7b, 11a-triaqzadibenzo[a, g]cycloocta[c, d, e]-trinden-1-one (KT5720), at dose of 10 pmol for 60 min, reversed the attenuation of the antinociceptive effect of DAMGO (5.6 ng, i.c.v.) caused by insulin. These results suggest that the reduction of DAMGO-induced antinociception by insulin in mice may be, in part, due to the activation of protein kinase C followed by the activation of tyrosine kinase." @default.
• W2039547211 created "2016-06-24" @default.
• W2039547211 creator A5053248719 @default.
• W2039547211 creator A5071224187 @default.
• W2039547211 creator A5073490682 @default.
• W2039547211 date "1999-06-01" @default.
• W2039547211 modified "2023-09-24" @default.
• W2039547211 title "Possible mechanisms for insulin-induced attenuation of the antinociceptive effect of [d-Ala2, N-MePhe4, Gly-ol5]enkephalin" @default.
• W2039547211 cites W1480299551 @default.
• W2039547211 cites W1492157617 @default.
• W2039547211 cites W1492465703 @default.
• W2039547211 cites W1511624316 @default.
• W2039547211 cites W1566898379 @default.
• W2039547211 cites W1572009433 @default.
• W2039547211 cites W1573285735 @default.
• W2039547211 cites W1964597676 @default.
• W2039547211 cites W1984159784 @default.
• W2039547211 cites W2023892739 @default.
• W2039547211 cites W2028006381 @default.
• W2039547211 cites W2032300794 @default.
• W2039547211 cites W2032359283 @default.
• W2039547211 cites W2038967651 @default.
• W2039547211 cites W2047780911 @default.
• W2039547211 cites W2048274927 @default.
• W2039547211 cites W2049133393 @default.
• W2039547211 cites W2051181567 @default.
• W2039547211 cites W2051221009 @default.
• W2039547211 cites W2053116212 @default.
• W2039547211 cites W2053799953 @default.
• W2039547211 cites W2057013554 @default.
• W2039547211 cites W2075473225 @default.
• W2039547211 cites W2075648913 @default.
• W2039547211 cites W2076876824 @default.
• W2039547211 cites W2079097756 @default.
• W2039547211 cites W2083482685 @default.
• W2039547211 cites W2088056954 @default.
• W2039547211 cites W2094985954 @default.
• W2039547211 cites W2118089530 @default.
• W2039547211 cites W2127122957 @default.
• W2039547211 cites W2136400536 @default.
• W2039547211 cites W2169507371 @default.
• W2039547211 cites W2184287036 @default.
• W2039547211 cites W2192686175 @default.
• W2039547211 cites W2340541742 @default.
• W2039547211 doi "https://doi.org/10.1016/s0014-2999(99)00273-3" @default.
• W2039547211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10414437" @default.
• W2039547211 hasPublicationYear "1999" @default.
• W2039547211 type Work @default.
• W2039547211 sameAs 2039547211 @default.
• W2039547211 citedByCount "7" @default.
• W2039547211 countsByYear W20395472112017 @default.
• W2039547211 crossrefType "journal-article" @default.
• W2039547211 hasAuthorship W2039547211A5053248719 @default.
• W2039547211 hasAuthorship W2039547211A5071224187 @default.
• W2039547211 hasAuthorship W2039547211A5073490682 @default.
• W2039547211 hasConcept C126322002 @default.
• W2039547211 hasConcept C134018914 @default.
• W2039547211 hasConcept C170493617 @default.
• W2039547211 hasConcept C184235292 @default.
• W2039547211 hasConcept C185592680 @default.
• W2039547211 hasConcept C195794163 @default.
• W2039547211 hasConcept C2776401185 @default.
• W2039547211 hasConcept C2777803847 @default.
• W2039547211 hasConcept C2779306644 @default.
• W2039547211 hasConcept C2780245509 @default.
• W2039547211 hasConcept C2781063702 @default.
• W2039547211 hasConcept C2781168148 @default.
• W2039547211 hasConcept C55493867 @default.
• W2039547211 hasConcept C71924100 @default.
• W2039547211 hasConcept C98274493 @default.
• W2039547211 hasConceptScore W2039547211C126322002 @default.
• W2039547211 hasConceptScore W2039547211C134018914 @default.
• W2039547211 hasConceptScore W2039547211C170493617 @default.
• W2039547211 hasConceptScore W2039547211C184235292 @default.
• W2039547211 hasConceptScore W2039547211C185592680 @default.
• W2039547211 hasConceptScore W2039547211C195794163 @default.
• W2039547211 hasConceptScore W2039547211C2776401185 @default.
• W2039547211 hasConceptScore W2039547211C2777803847 @default.
• W2039547211 hasConceptScore W2039547211C2779306644 @default.
• W2039547211 hasConceptScore W2039547211C2780245509 @default.
• W2039547211 hasConceptScore W2039547211C2781063702 @default.
• W2039547211 hasConceptScore W2039547211C2781168148 @default.
• W2039547211 hasConceptScore W2039547211C55493867 @default.
• W2039547211 hasConceptScore W2039547211C71924100 @default.
• W2039547211 hasConceptScore W2039547211C98274493 @default.
• W2039547211 hasIssue "2-3" @default.
• W2039547211 hasLocation W20395472111 @default.
• W2039547211 hasLocation W20395472112 @default.
• W2039547211 hasOpenAccess W2039547211 @default.
• W2039547211 hasPrimaryLocation W20395472111 @default.
• W2039547211 hasRelatedWork W1983641721 @default.
• W2039547211 hasRelatedWork W2018905790 @default.
• W2039547211 hasRelatedWork W2065201271 @default.
• W2039547211 hasRelatedWork W2066072901 @default.
• W2039547211 hasRelatedWork W2091237014 @default.
• W2039547211 hasRelatedWork W2094985954 @default.
• W2039547211 hasRelatedWork W2118089530 @default.
• W2039547211 hasRelatedWork W2127605085 @default.

• next