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- W2039554258 abstract "Prostate cancer is known as a disease with an extremely high prevalence relative to its clinical incidence in the population. The combination of preciinicai incidence and duration that could yield this phenomenon is of tremendous interest to researchers trying to understand the natural history of the disease and to develop efficient screening strategies. In this article, the authors present estimates of the age-specific asymptomatic incidence and average preciinicai duration of prostate cancer. The methodological approach is to first estimate the age-specific incidence of new (stage AI) prostate cancers using preciinicai prevalence data from autopsy studies performed between 1941 and 1964 and clinical incidence data for the years 1960-1986 from the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute. Then, the preciinicai prevalence estimates are divided by the derived preciinicai incidence estimates to yield estimates of the average duration of asymptomatic disease. The estimated mean duration among white men is between 11 and 12 years and appears to be approximately 1 year shorter for blacks than for whites. Comparison of the lifetime risks of preciinicai and clinical disease suggests that approximately 75% of prostate cancers will never become diagnosed if clinical incidence remains at levels observed in 1984-1986, prior to the introduction of prostate-specific antigen (PSA) screening in the population. Am J Epidemiol 1998; 148:775-85." @default.
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- W2039554258 date "1999-07-01" @default.
- W2039554258 modified "2023-10-01" @default.
- W2039554258 title "Asymptomatic Incidence and Duration of Prostate Cancer" @default.
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- W2039554258 doi "https://doi.org/10.1097/00005392-199907000-00083" @default.
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