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• W2039564595 abstract "Rest tremor at 4-6 Hz is typical for classical rest tremor (PT) of Parkinson's disease (PD). But rest tremor also appears in other tremor syndromes and may therefore cause a misdiagnosis. In this study we evaluated if suppression of tremor during movement onset is a characteristic feature of Parkinsonian Tremor distinguishing PT from Essential tremor (ET) and if this sign can be reliably diagnosed. Clinically diagnosed patients with PT (n = 44) and ET (n = 22) with rest tremor were included. Video sequences were recorded according to a standardized protocol focusing on the change of tremor amplitude during transition from rest to posture (test 1) or to a target-directed movement (test 2). These videos were assessed for rest tremor suppression by 4 reviewers (2 specialists and 2 residents) blinded to the clinical diagnosis and were compared to the personal assessment of an unblinded movement disorder specialist. Rest tremor suppression was found in 39/44 PD patients and in 2/22 patients with ET during the personal assessment. Rest tremor suppression showed a high sensitivity (0.92-1.00) and an acceptable specificity (0.69-0.95) for PD tremor in both tests. The interrater-reliability of the video-sequences was good to very good (κ 0.73-0.91). Less than 3% of the video sequences were misclassified. We conclude that the assessment of the suppression of rest tremor during movement initiation is a simple and reliable tool to separate PT from rest tremor in ET also suggesting that the mechanisms of rest tremor in these two diseases are different." @default.
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• W2039564595 date "2013-07-01" @default.
• W2039564595 modified "2023-10-18" @default.
• W2039564595 title "Rest tremor suppression may separate essential from parkinsonian rest tremor" @default.
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• W2039564595 doi "https://doi.org/10.1016/j.parkreldis.2013.03.013" @default.
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