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• W2039565543 endingPage "12" @default.
• W2039565543 startingPage "1" @default.
• W2039565543 abstract "NK cells represent a potential tool for adoptive immunotherapy against tumors. Membrane-bound Hsp70 acts as a tumor-specific marker enhancing NK cell activity. Using flow cytometry the effect of in vitro stimulation with IL-2 or IL-15 alone or in combination with Hsp70-derived 14-mer peptide (TKD) on cell surface expression of NK activatory receptors (CD16, NKG2D, NKG2C, NKp46, NKp44, NKp30, KIR2DL4, DNAM-1, and LAMP1) and NK inhibitory receptors (NKG2A, KIR2DL2/L3, LIR1/ILT-2, and NKR-P1A) in healthy individuals was studied. Results were expressed as the percentage of receptor expressing cells and the amount of receptor expressed by CD3(-)CD56(+) cellular population. CD94, NKG2D, NKp44, NKp30, KIR2DL4, DNAM-1, LAMP1, NKG2A, and NKR-P1A were upregulated after the stimulation with IL-2 or IL-15 alone or in combination with TKD. KIR2DL2/L3 was upregulated only by IL-15 and IL-15/TKD. Concurrently, an increase in a number of NK cells positive for CD94, NKp44, NKp30, KIR2DL4, and LAMP1 was observed. IL-15 and IL-15/TKD caused also cell number rise positive for KIR2DL2/L3 and NKR-P1A. Cell number positive for NKG2C and NKG2A was increased only by IL-2 and IL-2/TKD. The diverse effect of IL-2 or IL-15 w or w/o TKD on cell surface expression was observed in CD16, NKp46, and LIR1/ILT-2." @default.
• W2039565543 created "2016-06-24" @default.
• W2039565543 creator A5002856283 @default.
• W2039565543 creator A5011137508 @default.
• W2039565543 creator A5030571201 @default.
• W2039565543 date "2013-01-01" @default.
• W2039565543 modified "2023-10-03" @default.
• W2039565543 title "Influence of In Vitro IL-2 or IL-15 Alone or in Combination with Hsp-70-Derived 14-mer Peptide (TKD) on the Expression of NK Cell Activatory and Inhibitory Receptors" @default.
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• W2039565543 doi "https://doi.org/10.1155/2013/405295" @default.
• W2039565543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3588175" @default.
• W2039565543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23476104" @default.
• W2039565543 hasPublicationYear "2013" @default.
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