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- W2039573204 abstract "Human purified urokinase-type plasminogen activator (u-PA) stimulates chemoattractant activity for human neutrophils using modified Boyden chambers. Checkerboard analysis performed by adding different concentrations of u-PA above and below the polycarbonate filters revealed maximum migration required a positive concentration gradient. These results suggest that uPA was in fact stimulating neutrophil chemotaxis. Incubation of u-PA with an anti-u-PA goat antibody completely abolished the chemotactic activity of u-PA while incubation with the serine protease inhibitor, diisopropyl fluorophosphate, did not reduce chemotactic activity. Purified human tissue-type plasminogen activator demonstrated no chemotactic activity for human neutrophils when tested at concentrations similar to u-Pa. These results suggest that the expression of chemotactic activity of u-PA may serve to recruit circulating leukocytes to the inflammatory site." @default.
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- W2039573204 date "1987-09-01" @default.
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- W2039573204 title "Human urokinase-type plasminogen activator stimulates chemotaxis of human neutrophils" @default.
- W2039573204 doi "https://doi.org/10.1016/s0006-291x(87)80193-6" @default.
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