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- W2039590936 abstract "Purpose Late onset retinal degeneration is a hereditary condition characterized by progressive difficulty in dark adaptation and risk of choroidal neovascularisation. This in turn leads to a marked decline in visual acuity. We describe our experience treating a patient with a positive family history of late onset retinal degeneration who developed subfoveal choroidal neovascularisation.Methods Case report. A 57 year old Caucasian lady with a positive family history of late onset retinal degeneration and progressive decline in dark adaptation presented to us with a 1-week history of blurring of vision. Fundus fluorescein and indocyanine green angiography revealed a subfoveal classic neovascular membrane.Results Our patient was initially treated with intra-vitreal Ranibizumab and clinical activity of neovascularisation was monitored with serial spectral domain optical coherence tomography and visual acuity. Serial scans revealed recurrence of activity within a month of intra-vitreal Ranibizumab. With the advent of intra-vitreal Aflibercept, we offered our patient a change in treatment regime. Treatment with Aflibercept has thus far demonstrated a stabilization of disease activity on spectral domain optical coherence tomography and visual acuity for at least 8 weeks.Conclusion Whilst Ranibizumab and Aflibercept remain off-label for the treatment of late onset retinal degeneration, this suggests that Aflibercept is possibly more efficacious in the management of choroidal neovascular membranes in late onset retinal degeneration." @default.
- W2039590936 created "2016-06-24" @default.
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- W2039590936 date "2014-08-20" @default.
- W2039590936 modified "2023-09-27" @default.
- W2039590936 title "Management of choroidal neovascularisation in late onset retinal degeneration" @default.
- W2039590936 doi "https://doi.org/10.1111/j.1755-3768.2014.f068.x" @default.
- W2039590936 hasPublicationYear "2014" @default.
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