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• W2039596605 abstract "We previously suggested that endogenous interleukin-1β (IL-1β) produced by Porphyromonas gingivalis fimbriae stimulation in calvarial bone cell cultures plays a role in bone resorption as a major cytokine. Therefore, in the present study, we initiated experiments to clarify the stimulatory mechanism of IL-1β gene expression in fimbria-stimulated bone resorption. Fimbria-stimulated bone resorption was dramatically inhibited by curcumin, a potent inhibitor of activation protein-1 (AP-1). In fact, the fimbriae induced markedly both the expression of c-fos and c-jun genes and their protein production in the calvarial cells. In addition, a mixture of antisense oligonucleotides against c-fos and c-jun significantly inhibited not only the fimbria-induced expression of the IL-1β gene but also the fimbria-induced bone resorption. Therefore, the present study demonstrates that transcriptional factor AP-1 plays a functional role in P. gingivalis fimbria–stimulated bone resorption via endogenous IL-1β in the mouse calvarial system." @default.
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• W2039596605 date "2000-02-01" @default.
• W2039596605 modified "2023-09-27" @default.
• W2039596605 title "Role of transcriptional factor activation protein-1 in endogenous expression of the interleukin-1β gene involved in<i>Porphyromonas gingivalis</i>fimbria-stimulated bone resorption in the mouse calvarial system" @default.
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• W2039596605 doi "https://doi.org/10.1034/j.1399-302x.2000.150109.x" @default.
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