Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039598753> ?p ?o ?g. }
- W2039598753 endingPage "1689" @default.
- W2039598753 startingPage "1680" @default.
- W2039598753 abstract "Matrix metalloproteinases (MMP-9 and MMP-2) production and smooth muscle cell (SMC) migration may play key roles in the phathogenesis of neointima formation and atherosclerosis. Especially inducible MMP-9 expression was directly involved in the cancer cell invasion and SMC migration through vascular wall. In this study, we reveal that cryptotanshinone (CT) purified from Salvia miltiorrhiza BUNGE had an inhibitory effect on MMP-9 production and migration of human aortic smooth muscle cells treated with TNF-alpha in a dose-dependent manner. The down regulation of transcription of MMP-9 mRNA was evidenced by RT-PCR and MMP-9 promoter assay using luciferase reporter gene. Eletrophoretic mobility shift assay showed NF-kappaB and AP-1 nuclear translocations were suppressed. In addition, Western blot analysis indicated that extracellular signal regulated kinase 1 and 2, p38 and JNK MAP kinase signaling pathways were inhibited. From the results, it is suggested that CT has anti-atherosclerosis and anti-neointimal formation activity." @default.
- W2039598753 created "2016-06-24" @default.
- W2039598753 creator A5004995472 @default.
- W2039598753 creator A5032988440 @default.
- W2039598753 creator A5042439874 @default.
- W2039598753 creator A5043272237 @default.
- W2039598753 creator A5043410416 @default.
- W2039598753 creator A5057986515 @default.
- W2039598753 creator A5074483970 @default.
- W2039598753 creator A5077403603 @default.
- W2039598753 creator A5078230131 @default.
- W2039598753 creator A5084148795 @default.
- W2039598753 creator A5091456984 @default.
- W2039598753 date "2006-12-01" @default.
- W2039598753 modified "2023-09-27" @default.
- W2039598753 title "Cryptotanshinone from Salvia miltiorrhiza BUNGE has an inhibitory effect on TNF-α-induced matrix metalloproteinase-9 production and HASMC migration via down-regulated NF-κB and AP-1" @default.
- W2039598753 cites W1491678226 @default.
- W2039598753 cites W1571553794 @default.
- W2039598753 cites W1591653197 @default.
- W2039598753 cites W1617532721 @default.
- W2039598753 cites W1846208898 @default.
- W2039598753 cites W1966765457 @default.
- W2039598753 cites W1974538333 @default.
- W2039598753 cites W1974897112 @default.
- W2039598753 cites W1978504014 @default.
- W2039598753 cites W1980431956 @default.
- W2039598753 cites W1994590258 @default.
- W2039598753 cites W1996568411 @default.
- W2039598753 cites W1996610886 @default.
- W2039598753 cites W2001793664 @default.
- W2039598753 cites W2023862918 @default.
- W2039598753 cites W2024040688 @default.
- W2039598753 cites W2043186800 @default.
- W2039598753 cites W2061755142 @default.
- W2039598753 cites W2062950088 @default.
- W2039598753 cites W2069688010 @default.
- W2039598753 cites W2070997026 @default.
- W2039598753 cites W207753262 @default.
- W2039598753 cites W2080043159 @default.
- W2039598753 cites W2082081437 @default.
- W2039598753 cites W2083771462 @default.
- W2039598753 cites W2088041505 @default.
- W2039598753 cites W2090011997 @default.
- W2039598753 cites W2092733898 @default.
- W2039598753 cites W2093629370 @default.
- W2039598753 cites W2100206828 @default.
- W2039598753 cites W2129554772 @default.
- W2039598753 cites W2134471349 @default.
- W2039598753 cites W2137570167 @default.
- W2039598753 cites W2143689100 @default.
- W2039598753 cites W2150682250 @default.
- W2039598753 cites W2151426663 @default.
- W2039598753 cites W2152845778 @default.
- W2039598753 cites W2153141596 @default.
- W2039598753 cites W2156552442 @default.
- W2039598753 cites W2160768910 @default.
- W2039598753 cites W2163960849 @default.
- W2039598753 cites W2169095915 @default.
- W2039598753 cites W4248973968 @default.
- W2039598753 doi "https://doi.org/10.1016/j.bcp.2006.08.013" @default.
- W2039598753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16999937" @default.
- W2039598753 hasPublicationYear "2006" @default.
- W2039598753 type Work @default.
- W2039598753 sameAs 2039598753 @default.
- W2039598753 citedByCount "54" @default.
- W2039598753 countsByYear W20395987532012 @default.
- W2039598753 countsByYear W20395987532013 @default.
- W2039598753 countsByYear W20395987532014 @default.
- W2039598753 countsByYear W20395987532015 @default.
- W2039598753 countsByYear W20395987532016 @default.
- W2039598753 countsByYear W20395987532017 @default.
- W2039598753 countsByYear W20395987532018 @default.
- W2039598753 countsByYear W20395987532019 @default.
- W2039598753 countsByYear W20395987532021 @default.
- W2039598753 countsByYear W20395987532022 @default.
- W2039598753 crossrefType "journal-article" @default.
- W2039598753 hasAuthorship W2039598753A5004995472 @default.
- W2039598753 hasAuthorship W2039598753A5032988440 @default.
- W2039598753 hasAuthorship W2039598753A5042439874 @default.
- W2039598753 hasAuthorship W2039598753A5043272237 @default.
- W2039598753 hasAuthorship W2039598753A5043410416 @default.
- W2039598753 hasAuthorship W2039598753A5057986515 @default.
- W2039598753 hasAuthorship W2039598753A5074483970 @default.
- W2039598753 hasAuthorship W2039598753A5077403603 @default.
- W2039598753 hasAuthorship W2039598753A5078230131 @default.
- W2039598753 hasAuthorship W2039598753A5084148795 @default.
- W2039598753 hasAuthorship W2039598753A5091456984 @default.
- W2039598753 hasConcept C104317684 @default.
- W2039598753 hasConcept C109523444 @default.
- W2039598753 hasConcept C111335760 @default.
- W2039598753 hasConcept C126322002 @default.
- W2039598753 hasConcept C134018914 @default.
- W2039598753 hasConcept C137738243 @default.
- W2039598753 hasConcept C142724271 @default.
- W2039598753 hasConcept C1491633281 @default.
- W2039598753 hasConcept C150194340 @default.
- W2039598753 hasConcept C153911025 @default.
- W2039598753 hasConcept C161733203 @default.