Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039601123> ?p ?o ?g. }
- W2039601123 endingPage "723" @default.
- W2039601123 startingPage "718" @default.
- W2039601123 abstract "Cardiac hypertrophy is a common response to pressure overload and is associated with increased mortality. Mechanical stress in the heart results in the activation of the small GTPase ras and the Raf-1/MEK/ERK signaling cascade in addition to other signaling pathways.In an attempt to determine the requirement for the serine/threonine kinase Raf-1 in the pathogenesis of cardiac hypertrophy, we generated transgenic mice with cardiac-specific expression of a dominant negative form of Raf-1 (DN-Raf). DN-Raf mice appeared normal at birth, were fertile, and had normal cardiac structure and function in the absence of provocative stimulation. In response to pressure overload, cardiac extracellular signal-regulated kinase (ERK) activation was inhibited, but c-Jun N-terminal kinase (JNK) activation and p38 mitogen-activated protein kinase (MAPK) activation were normal. DN-Raf mice were sensitized to pressure overload and the development of cardiomyocyte apoptosis, and >35% of animals died within 7 days of aortic banding. Surviving DN-Raf animals were markedly resistant to the development of cardiac hypertrophy and hypertrophic gene induction in response to transverse aortic constriction.These results establish that Raf-1 kinase activity is essential for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload." @default.
- W2039601123 created "2016-06-24" @default.
- W2039601123 creator A5003204361 @default.
- W2039601123 creator A5007118272 @default.
- W2039601123 creator A5033734762 @default.
- W2039601123 creator A5052131456 @default.
- W2039601123 creator A5057539382 @default.
- W2039601123 creator A5059781186 @default.
- W2039601123 date "2004-08-10" @default.
- W2039601123 modified "2023-09-25" @default.
- W2039601123 title "Raf-1 Kinase Is Required for Cardiac Hypertrophy and Cardiomyocyte Survival in Response to Pressure Overload" @default.
- W2039601123 cites W1504962329 @default.
- W2039601123 cites W1524149821 @default.
- W2039601123 cites W1533702935 @default.
- W2039601123 cites W1964541624 @default.
- W2039601123 cites W1975857526 @default.
- W2039601123 cites W1978231615 @default.
- W2039601123 cites W1987510108 @default.
- W2039601123 cites W1988493115 @default.
- W2039601123 cites W1996738230 @default.
- W2039601123 cites W2004147779 @default.
- W2039601123 cites W2027660679 @default.
- W2039601123 cites W2029231027 @default.
- W2039601123 cites W2035026459 @default.
- W2039601123 cites W2035301267 @default.
- W2039601123 cites W2039202467 @default.
- W2039601123 cites W2050598970 @default.
- W2039601123 cites W2054779757 @default.
- W2039601123 cites W2056009784 @default.
- W2039601123 cites W2056829959 @default.
- W2039601123 cites W2062427243 @default.
- W2039601123 cites W2066367871 @default.
- W2039601123 cites W2067524077 @default.
- W2039601123 cites W2076860978 @default.
- W2039601123 cites W2080520906 @default.
- W2039601123 cites W2086041680 @default.
- W2039601123 cites W2095974846 @default.
- W2039601123 cites W2107168679 @default.
- W2039601123 cites W2119370228 @default.
- W2039601123 cites W2123481720 @default.
- W2039601123 cites W2127154429 @default.
- W2039601123 cites W2134128731 @default.
- W2039601123 cites W2151357723 @default.
- W2039601123 cites W2155591792 @default.
- W2039601123 cites W2162297869 @default.
- W2039601123 cites W2164313332 @default.
- W2039601123 cites W2179216392 @default.
- W2039601123 cites W2278536347 @default.
- W2039601123 cites W4232264475 @default.
- W2039601123 cites W4239714346 @default.
- W2039601123 doi "https://doi.org/10.1161/01.cir.0000138190.50127.6a" @default.
- W2039601123 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15289381" @default.
- W2039601123 hasPublicationYear "2004" @default.
- W2039601123 type Work @default.
- W2039601123 sameAs 2039601123 @default.
- W2039601123 citedByCount "154" @default.
- W2039601123 countsByYear W20396011232012 @default.
- W2039601123 countsByYear W20396011232013 @default.
- W2039601123 countsByYear W20396011232014 @default.
- W2039601123 countsByYear W20396011232015 @default.
- W2039601123 countsByYear W20396011232016 @default.
- W2039601123 countsByYear W20396011232017 @default.
- W2039601123 countsByYear W20396011232018 @default.
- W2039601123 countsByYear W20396011232019 @default.
- W2039601123 countsByYear W20396011232020 @default.
- W2039601123 countsByYear W20396011232021 @default.
- W2039601123 countsByYear W20396011232022 @default.
- W2039601123 countsByYear W20396011232023 @default.
- W2039601123 crossrefType "journal-article" @default.
- W2039601123 hasAuthorship W2039601123A5003204361 @default.
- W2039601123 hasAuthorship W2039601123A5007118272 @default.
- W2039601123 hasAuthorship W2039601123A5033734762 @default.
- W2039601123 hasAuthorship W2039601123A5052131456 @default.
- W2039601123 hasAuthorship W2039601123A5057539382 @default.
- W2039601123 hasAuthorship W2039601123A5059781186 @default.
- W2039601123 hasBestOaLocation W20396011231 @default.
- W2039601123 hasConcept C124160383 @default.
- W2039601123 hasConcept C126322002 @default.
- W2039601123 hasConcept C134018914 @default.
- W2039601123 hasConcept C167414201 @default.
- W2039601123 hasConcept C184235292 @default.
- W2039601123 hasConcept C2778271984 @default.
- W2039601123 hasConcept C3018791406 @default.
- W2039601123 hasConcept C57074206 @default.
- W2039601123 hasConcept C71924100 @default.
- W2039601123 hasConcept C86803240 @default.
- W2039601123 hasConcept C90934575 @default.
- W2039601123 hasConcept C95444343 @default.
- W2039601123 hasConcept C97029542 @default.
- W2039601123 hasConceptScore W2039601123C124160383 @default.
- W2039601123 hasConceptScore W2039601123C126322002 @default.
- W2039601123 hasConceptScore W2039601123C134018914 @default.
- W2039601123 hasConceptScore W2039601123C167414201 @default.
- W2039601123 hasConceptScore W2039601123C184235292 @default.
- W2039601123 hasConceptScore W2039601123C2778271984 @default.
- W2039601123 hasConceptScore W2039601123C3018791406 @default.
- W2039601123 hasConceptScore W2039601123C57074206 @default.
- W2039601123 hasConceptScore W2039601123C71924100 @default.