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- W2039602871 endingPage "699" @default.
- W2039602871 startingPage "690" @default.
- W2039602871 abstract "The neurochemical basis of depression focuses on alterations in the monoaminergic and amino acid neurotransmitter systems. Moreover, decreases in serum levels of the neurotrophin brain-derived neurotrophic factor (BDNF) have led to the more recent neurotrophic hypothesis of depression. Chronic stress is one of the major predisposing factors to developing the disorder and thus we investigated the impact of chronic restraint stress on the levels of several neurotransmitters and their metabolites in a genetic animal model of depression, the Wistar Kyoto (WKY) rat. Behavioural analysis of WKY rats indicated both a depressive and anxiety-like phenotype compared to their Sprague Dawley (SD) controls. WKY animals showed similar stress-induced decreases in hippocampal GABA, noradrenaline and dopamine as their SD counterparts while exhibiting a divergent decrease in 5-HT, 5-HIAA and DOPAC. WKY rats also showed a stress-dependant increase in GABA concentrations in the amygdala compared to the SD animals. Moreover, WKY but not SD rats had a chronic stress-induced decrease in serum BDNF levels. Together these data show that there are specific strain-dependent changes in neurotransmitter and neurotrophin levels in response to chronic stress which may predispose WKY animals to a depressive-like phenotype." @default.
- W2039602871 created "2016-06-24" @default.
- W2039602871 creator A5003021083 @default.
- W2039602871 creator A5048782526 @default.
- W2039602871 creator A5072340849 @default.
- W2039602871 creator A5084928512 @default.
- W2039602871 creator A5087830456 @default.
- W2039602871 date "2011-02-01" @default.
- W2039602871 modified "2023-09-30" @default.
- W2039602871 title "Strain differences in the neurochemical response to chronic restraint stress in the rat: Relevance to depression" @default.
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