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• W2039606881 abstract "ABSTRACT Interleukin 10 (IL‐10) is a potent immunosuppressive cytokine, therefore elevated IL‐10 expression has been implicated in inhibition of antitumor immune response. IL‐10 gene promoter polymorphism has been shown to be involved in susceptibility to skin cancers, but there has been no report focusing on susceptibility to skin cancers among non‐Caucasian populations. We enrolled 129 patients with skin cancers and 50 age‐ and sex‐matched healthy controls between April 2004 and March 2007. Genomic DNA was extracted from patients’ blood samples and IL‐10 promoter polymorphisms were identified using polymerase chain reaction‐restriction fragment length polymorphism or direct sequencing. The distribution of the frequency of allele or haplotype of IL‐10 gene promoter in Japanese was quite different from that of Europeans. No significant differences could be demonstrated in the frequency of allele or haplotype of IL‐10 gene promoter between the patient group and the control group. However, the frequency of the low‐IL‐10 expression haplotype was significantly high in Bowen’s disease subgroup. The frequency of low expression IL‐10 promoter genotype was significantly less ( P = 0.009, χ 2 = 6.74) in the group of nonmelanoma skin cancer generated on sun‐exposed areas in comparison with that on covered areas. Our results indicated that low expression haplotype of IL‐10 in Bowen’s disease may inhibit the escape of tumor cells from immune surveillance, resulting in suppression of tumor growth and tumor invasion to the dermis. Moreover, high IL‐10‐expressing haplotype of IL‐10 promoter may be a risk factor for photocarcinogenesis." @default.
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• W2039606881 date "2007-12-10" @default.
• W2039606881 modified "2023-09-30" @default.
• W2039606881 title "Involvement of Interleukin-10 Promoter Polymorphisms in Nonmelanoma Skin Cancers-A Case Study in Non-Caucasian Skin Cancer Patients†" @default.
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• W2039606881 doi "https://doi.org/10.1111/j.1751-1097.2007.00245.x" @default.
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