SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039620145> ?p ?o ?g. }

Showing items 1 to 100 of ±102 with 100 items per page.

W2039620145 abstract "Schizandrae chinensis, a traditional Chinese medicine herb, has been used to treat hepatitis B disease in Chinese hospital clinic. We have isolated two bioactive compounds, deoxyschizandrin and gamma-schizandrin, from S. chinensis. In the present, we reported that deoxyschizandrin and gamma-schizandrin could induce apoptosis in human promyelocytic leukemia cells (HL-60), as characterized by DNA fragmentation and poly (ADP) ribose polymerase (PARP) cleavage. Further molecular analysis showed that deoxyschizandrin and gamma-schizandrin caused the loss of mitochondrial membrane potential (DeltaPsim), cytochrome c release from mitochondrion to cytosol, truncation of Bid protein, and activation of caspase-3 and -9. However, they did not increase the intracellular level of reactive oxygen species (ROS). Antioxidants such as N-acetyl cysteine (NAC) and catalase did not block the apoptosis induced by deoxyschizandrin or gamma-schizandrin. These findings suggest that deoxyschizandrin and gamma-schizandrin-induced apoptosis in HL-60 cells involved ROS-independent mitochondrial dysfunction pathway." @default.
W2039620145 created "2016-06-24" @default.
W2039620145 creator A5016261214 @default.
W2039620145 creator A5022218511 @default.
W2039620145 creator A5069288315 @default.
W2039620145 date "2008-02-01" @default.
W2039620145 modified "2023-10-18" @default.
W2039620145 title "Molecular mechanism of apoptosis induced by schizandrae-derived lignans in human leukemia HL-60 cells" @default.
W2039620145 cites W142202837 @default.
W2039620145 cites W1506642042 @default.
W2039620145 cites W1587890084 @default.
W2039620145 cites W1950405118 @default.
W2039620145 cites W1967912613 @default.
W2039620145 cites W1974980101 @default.
W2039620145 cites W1979842763 @default.
W2039620145 cites W1996180957 @default.
W2039620145 cites W1997005484 @default.
W2039620145 cites W2002763506 @default.
W2039620145 cites W2004619216 @default.
W2039620145 cites W2009351346 @default.
W2039620145 cites W2024983745 @default.
W2039620145 cites W2045315429 @default.
W2039620145 cites W2049110705 @default.
W2039620145 cites W2061497413 @default.
W2039620145 cites W2061690334 @default.
W2039620145 cites W2063317805 @default.
W2039620145 cites W2069051806 @default.
W2039620145 cites W2069542816 @default.
W2039620145 cites W2072252062 @default.
W2039620145 cites W2087900954 @default.
W2039620145 cites W2100033931 @default.
W2039620145 cites W2119683782 @default.
W2039620145 cites W2137157955 @default.
W2039620145 cites W2145694409 @default.
W2039620145 cites W2167504781 @default.
W2039620145 doi "https://doi.org/10.1016/j.fct.2007.08.048" @default.
W2039620145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17950515" @default.
W2039620145 hasPublicationYear "2008" @default.
W2039620145 type Work @default.
W2039620145 sameAs 2039620145 @default.
W2039620145 citedByCount "20" @default.
W2039620145 countsByYear W20396201452012 @default.
W2039620145 countsByYear W20396201452013 @default.
W2039620145 countsByYear W20396201452014 @default.
W2039620145 countsByYear W20396201452019 @default.
W2039620145 countsByYear W20396201452020 @default.
W2039620145 crossrefType "journal-article" @default.
W2039620145 hasAuthorship W2039620145A5016261214 @default.
W2039620145 hasAuthorship W2039620145A5022218511 @default.
W2039620145 hasAuthorship W2039620145A5069288315 @default.
W2039620145 hasConcept C181199279 @default.
W2039620145 hasConcept C182979987 @default.
W2039620145 hasConcept C185592680 @default.
W2039620145 hasConcept C190283241 @default.
W2039620145 hasConcept C28859421 @default.
W2039620145 hasConcept C29311851 @default.
W2039620145 hasConcept C31573885 @default.
W2039620145 hasConcept C43759708 @default.
W2039620145 hasConcept C48349386 @default.
W2039620145 hasConcept C552990157 @default.
W2039620145 hasConcept C55493867 @default.
W2039620145 hasConcept C71924100 @default.
W2039620145 hasConcept C82381507 @default.
W2039620145 hasConcept C86803240 @default.
W2039620145 hasConcept C95444343 @default.
W2039620145 hasConcept C98424977 @default.
W2039620145 hasConcept C98539663 @default.
W2039620145 hasConceptScore W2039620145C181199279 @default.
W2039620145 hasConceptScore W2039620145C182979987 @default.
W2039620145 hasConceptScore W2039620145C185592680 @default.
W2039620145 hasConceptScore W2039620145C190283241 @default.
W2039620145 hasConceptScore W2039620145C28859421 @default.
W2039620145 hasConceptScore W2039620145C29311851 @default.
W2039620145 hasConceptScore W2039620145C31573885 @default.
W2039620145 hasConceptScore W2039620145C43759708 @default.
W2039620145 hasConceptScore W2039620145C48349386 @default.
W2039620145 hasConceptScore W2039620145C552990157 @default.
W2039620145 hasConceptScore W2039620145C55493867 @default.
W2039620145 hasConceptScore W2039620145C71924100 @default.
W2039620145 hasConceptScore W2039620145C82381507 @default.
W2039620145 hasConceptScore W2039620145C86803240 @default.
W2039620145 hasConceptScore W2039620145C95444343 @default.
W2039620145 hasConceptScore W2039620145C98424977 @default.
W2039620145 hasConceptScore W2039620145C98539663 @default.
W2039620145 hasLocation W20396201451 @default.
W2039620145 hasLocation W20396201452 @default.
W2039620145 hasOpenAccess W2039620145 @default.
W2039620145 hasPrimaryLocation W20396201451 @default.
W2039620145 hasRelatedWork W1570628773 @default.
W2039620145 hasRelatedWork W1997217890 @default.
W2039620145 hasRelatedWork W2009627704 @default.
W2039620145 hasRelatedWork W2020308594 @default.
W2039620145 hasRelatedWork W2039521078 @default.
W2039620145 hasRelatedWork W2065323371 @default.
W2039620145 hasRelatedWork W2146598214 @default.
W2039620145 hasRelatedWork W2249121318 @default.
W2039620145 hasRelatedWork W2366219004 @default.
W2039620145 hasRelatedWork W4248625814 @default.
W2039620145 isParatext "false" @default.
W2039620145 isRetracted "false" @default.