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- W2039622113 endingPage "790" @default.
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- W2039622113 abstract "Abstract The bisintercalator natural products are a family of nonribosomal peptides possessing a range of biological properties that include antiviral, antibiotic, and anticancer activities. The name bisintercalator is derived from the ability to directly bind to duplex DNA through two planar intercalating moieties. Although 19 members of this family of compounds have been identified over the past 50 years, the biosynthetic genes responsible for the formation of four of these molecules (thiocoraline, SW‐163, triostin A, and echinomycin) were identified only recently. This recent progress opens an avenue towards understanding how Nature produces these bisintercalating products and provides the potential to develop and identify novel potent analogous lead compounds for clinical applications. This review discusses the mode of action of bisintercalators and summarizes recent genetic and biochemical insights into their biosynthetic production, analog formation, and possible mechanisms by which resistance to these compounds is achieved by their producing organisms. © 2010 Wiley Periodicals, Inc. Biopolymers 93: 777–790, 2010." @default.
- W2039622113 created "2016-06-24" @default.
- W2039622113 creator A5021345410 @default.
- W2039622113 creator A5029326229 @default.
- W2039622113 creator A5081914624 @default.
- W2039622113 date "2010-06-23" @default.
- W2039622113 modified "2023-10-17" @default.
- W2039622113 title "Recent developments in bisintercalator natural products" @default.
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- W2039622113 doi "https://doi.org/10.1002/bip.21489" @default.
- W2039622113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20578002" @default.
- W2039622113 hasPublicationYear "2010" @default.