Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039626021> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2039626021 endingPage "200" @default.
- W2039626021 startingPage "181" @default.
- W2039626021 abstract "Expression of estramustine-binding protein (EMBP) was determined in eight variants of the Dunning R3327 rat prostate adenocarcinoma. This secretory protein was previously isolated from the normal rat prostate and binds estramustine and estromustine, the metabolites exerting anti-mitotic and anti-proliferative activity of the anticancer agent estramustine phosphate (EstracytR). EMBP was found in relatively high amounts only in the androgen-responsive G and H tumors from intact hosts, whereas low (AT-1, HI-F) or nondetectable levels (HI-S, AT-3, MAT-LyLu, MAT-Lu) were obtained in the androgen-independent tumors. Castration decreased EMBP expression in both G and H tumors, as did estradiol and estramustine when given separately to intact rats. Supplementation of castrates with exogenous androgen stimulated EMBP expression above the pre-castration level and was further enhanced when combined with estradiol and in particular estramustine. Partial physicochemical characterization of EMBP in G and H tumors was performed by using ligand-based and immunoblotting techniques. [3H]Estromustine was bound to cytosols and salt extracts from tumors with the same affinity and displayed similar surface-charge distribution, sedimentation behavior, and subunit composition as found for ventral and dorsolateral prostatic tissue from tumor-bearing rats. This study indicates that the synthesis of EMBP is under androgenic control and that its expression may be correlated to androgen responsiveness, metastatic potential, and androgen receptor content but not to growth rate and morphology of the tumors. EMBP may therefore provide a mechanism for concentration of cytotoxic activity at the target site in EMBP-positive tumors and help in the evaluation of antitumor effects obtained when administering estramustine." @default.
- W2039626021 created "2016-06-24" @default.
- W2039626021 creator A5032227006 @default.
- W2039626021 creator A5043265453 @default.
- W2039626021 creator A5070704455 @default.
- W2039626021 date "1991-01-01" @default.
- W2039626021 modified "2023-09-24" @default.
- W2039626021 title "Estramustine binding protein (EMBP) in rat R3327 dunning tumors: Partial characterization and effect of hormonal withdrawal, hormonal replacement, and cytotoxic treatment on its expression" @default.
- W2039626021 cites W140056640 @default.
- W2039626021 cites W1503990829 @default.
- W2039626021 cites W1967635178 @default.
- W2039626021 cites W1977169383 @default.
- W2039626021 cites W1983649348 @default.
- W2039626021 cites W1985365631 @default.
- W2039626021 cites W1994099444 @default.
- W2039626021 cites W1994600790 @default.
- W2039626021 cites W1996481062 @default.
- W2039626021 cites W1997963564 @default.
- W2039626021 cites W2003024052 @default.
- W2039626021 cites W2004666046 @default.
- W2039626021 cites W2045451331 @default.
- W2039626021 cites W2057218203 @default.
- W2039626021 cites W2071005840 @default.
- W2039626021 cites W2100150359 @default.
- W2039626021 cites W2101166589 @default.
- W2039626021 cites W2136114412 @default.
- W2039626021 cites W2396982863 @default.
- W2039626021 cites W2423950142 @default.
- W2039626021 cites W2435077941 @default.
- W2039626021 cites W4232534952 @default.
- W2039626021 doi "https://doi.org/10.1002/pros.2990180302" @default.
- W2039626021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2020618" @default.
- W2039626021 hasPublicationYear "1991" @default.
- W2039626021 type Work @default.
- W2039626021 sameAs 2039626021 @default.
- W2039626021 citedByCount "11" @default.
- W2039626021 crossrefType "journal-article" @default.
- W2039626021 hasAuthorship W2039626021A5032227006 @default.
- W2039626021 hasAuthorship W2039626021A5043265453 @default.
- W2039626021 hasAuthorship W2039626021A5070704455 @default.
- W2039626021 hasConcept C121608353 @default.
- W2039626021 hasConcept C126322002 @default.
- W2039626021 hasConcept C134018914 @default.
- W2039626021 hasConcept C154317977 @default.
- W2039626021 hasConcept C185592680 @default.
- W2039626021 hasConcept C202751555 @default.
- W2039626021 hasConcept C2776235491 @default.
- W2039626021 hasConcept C2777911890 @default.
- W2039626021 hasConcept C2779256933 @default.
- W2039626021 hasConcept C2780192828 @default.
- W2039626021 hasConcept C2780201970 @default.
- W2039626021 hasConcept C2994223898 @default.
- W2039626021 hasConcept C502942594 @default.
- W2039626021 hasConcept C55493867 @default.
- W2039626021 hasConcept C61367390 @default.
- W2039626021 hasConcept C71315377 @default.
- W2039626021 hasConcept C71924100 @default.
- W2039626021 hasConcept C86803240 @default.
- W2039626021 hasConceptScore W2039626021C121608353 @default.
- W2039626021 hasConceptScore W2039626021C126322002 @default.
- W2039626021 hasConceptScore W2039626021C134018914 @default.
- W2039626021 hasConceptScore W2039626021C154317977 @default.
- W2039626021 hasConceptScore W2039626021C185592680 @default.
- W2039626021 hasConceptScore W2039626021C202751555 @default.
- W2039626021 hasConceptScore W2039626021C2776235491 @default.
- W2039626021 hasConceptScore W2039626021C2777911890 @default.
- W2039626021 hasConceptScore W2039626021C2779256933 @default.
- W2039626021 hasConceptScore W2039626021C2780192828 @default.
- W2039626021 hasConceptScore W2039626021C2780201970 @default.
- W2039626021 hasConceptScore W2039626021C2994223898 @default.
- W2039626021 hasConceptScore W2039626021C502942594 @default.
- W2039626021 hasConceptScore W2039626021C55493867 @default.
- W2039626021 hasConceptScore W2039626021C61367390 @default.
- W2039626021 hasConceptScore W2039626021C71315377 @default.
- W2039626021 hasConceptScore W2039626021C71924100 @default.
- W2039626021 hasConceptScore W2039626021C86803240 @default.
- W2039626021 hasIssue "3" @default.
- W2039626021 hasLocation W20396260211 @default.
- W2039626021 hasLocation W20396260212 @default.
- W2039626021 hasOpenAccess W2039626021 @default.
- W2039626021 hasPrimaryLocation W20396260211 @default.
- W2039626021 hasRelatedWork W2004261902 @default.
- W2039626021 hasRelatedWork W2007905997 @default.
- W2039626021 hasRelatedWork W2014676068 @default.
- W2039626021 hasRelatedWork W2023266651 @default.
- W2039626021 hasRelatedWork W2046085320 @default.
- W2039626021 hasRelatedWork W2068395526 @default.
- W2039626021 hasRelatedWork W2072661483 @default.
- W2039626021 hasRelatedWork W2103250319 @default.
- W2039626021 hasRelatedWork W2116930034 @default.
- W2039626021 hasRelatedWork W2171723716 @default.
- W2039626021 hasVolume "18" @default.
- W2039626021 isParatext "false" @default.
- W2039626021 isRetracted "false" @default.
- W2039626021 magId "2039626021" @default.
- W2039626021 workType "article" @default.