Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039626364> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2039626364 endingPage "851" @default.
- W2039626364 startingPage "844" @default.
- W2039626364 abstract "Flow cytometrically determined cellular DNA content has been measured on specimens from 101 patients affected by lung cancer (40 epidermoid cell carcinoma, 22 adenocarcinoma, 21 large cell carcinoma, 11 small cell carcinoma, and seven undifferentiated carcinoma), and one by mesothelioma. Ninety-eight of 102 (96%) patients with neoplastic disease evidenced the occurrence of at least one cytometrically aneuploid cell subpopulation. Fifty-five of 102 (54%) cases evidenced the occurrence of multiclonality, that is, the presence of more than one aneuploid stem cell line. However, the incidence of multiclonality in lung carcinoma was statistically different in surgical cases (where multiple site sampling from the primary and lymph nodes was possible) in comparison to the nonsurgical ones (e.g., bronchial washing): 48/77 (62%) and six of 24 (25%), respectively. Therefore, only the 77 surgical patients were used for further analysis. The cases were classified according to the DNA index (DI) in the following way: Group A (tumors with one or more stem lines with DI ranging from 1 to 2) and Group B (tumors with at least one stem line with DI less than 1 or greater than 2). A significant correlation has been found between the cytometric ploidy condition so defined (Groups A and B) and the tumor mass doubling time (DT), Group B being associated with fast growing tumors (DT lower than 90 days). A statistically better 12-month survival rate (5-year maximum follow-up) was observed in Group A (88%) in respect to Group B (47%) and is evident in the patient survival time course. A better prognostic indication can be achieved by stratifying the patients according to both the cytometric ploidy condition and the tumor DT. Flow cytometric data can usefully contribute to the prognostic assessment of lung carcinoma provided that representative cellular material is collected by multiple site sampling." @default.
- W2039626364 created "2016-06-24" @default.
- W2039626364 creator A5000569767 @default.
- W2039626364 creator A5004568900 @default.
- W2039626364 creator A5011100084 @default.
- W2039626364 creator A5015096493 @default.
- W2039626364 creator A5019614566 @default.
- W2039626364 creator A5075332996 @default.
- W2039626364 creator A5075782791 @default.
- W2039626364 date "1987-08-15" @default.
- W2039626364 modified "2023-10-17" @default.
- W2039626364 title "Prognostic significance of flow cytometry in lung cancer. A 5-year study" @default.
- W2039626364 cites W1590578494 @default.
- W2039626364 cites W1968166929 @default.
- W2039626364 cites W1969551117 @default.
- W2039626364 cites W1974548614 @default.
- W2039626364 cites W1993757818 @default.
- W2039626364 cites W2005266513 @default.
- W2039626364 cites W2014891128 @default.
- W2039626364 cites W2036802451 @default.
- W2039626364 cites W2040109962 @default.
- W2039626364 cites W2079655977 @default.
- W2039626364 cites W2084063599 @default.
- W2039626364 cites W2090761087 @default.
- W2039626364 cites W2413395556 @default.
- W2039626364 cites W2470667381 @default.
- W2039626364 cites W4293241248 @default.
- W2039626364 cites W259029587 @default.
- W2039626364 doi "https://doi.org/10.1002/1097-0142(19870815)60:4<844::aid-cncr2820600421>3.0.co;2-3" @default.
- W2039626364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3594402" @default.
- W2039626364 hasPublicationYear "1987" @default.
- W2039626364 type Work @default.
- W2039626364 sameAs 2039626364 @default.
- W2039626364 citedByCount "102" @default.
- W2039626364 countsByYear W20396263642012 @default.
- W2039626364 countsByYear W20396263642017 @default.
- W2039626364 countsByYear W20396263642019 @default.
- W2039626364 crossrefType "journal-article" @default.
- W2039626364 hasAuthorship W2039626364A5000569767 @default.
- W2039626364 hasAuthorship W2039626364A5004568900 @default.
- W2039626364 hasAuthorship W2039626364A5011100084 @default.
- W2039626364 hasAuthorship W2039626364A5015096493 @default.
- W2039626364 hasAuthorship W2039626364A5019614566 @default.
- W2039626364 hasAuthorship W2039626364A5075332996 @default.
- W2039626364 hasAuthorship W2039626364A5075782791 @default.
- W2039626364 hasBestOaLocation W20396263641 @default.
- W2039626364 hasConcept C121608353 @default.
- W2039626364 hasConcept C126322002 @default.
- W2039626364 hasConcept C142724271 @default.
- W2039626364 hasConcept C1491633281 @default.
- W2039626364 hasConcept C203014093 @default.
- W2039626364 hasConcept C2776256026 @default.
- W2039626364 hasConcept C2777546739 @default.
- W2039626364 hasConcept C2778911148 @default.
- W2039626364 hasConcept C2779292878 @default.
- W2039626364 hasConcept C2781182431 @default.
- W2039626364 hasConcept C48900799 @default.
- W2039626364 hasConcept C54355233 @default.
- W2039626364 hasConcept C553184892 @default.
- W2039626364 hasConcept C71924100 @default.
- W2039626364 hasConcept C86803240 @default.
- W2039626364 hasConcept C90924648 @default.
- W2039626364 hasConceptScore W2039626364C121608353 @default.
- W2039626364 hasConceptScore W2039626364C126322002 @default.
- W2039626364 hasConceptScore W2039626364C142724271 @default.
- W2039626364 hasConceptScore W2039626364C1491633281 @default.
- W2039626364 hasConceptScore W2039626364C203014093 @default.
- W2039626364 hasConceptScore W2039626364C2776256026 @default.
- W2039626364 hasConceptScore W2039626364C2777546739 @default.
- W2039626364 hasConceptScore W2039626364C2778911148 @default.
- W2039626364 hasConceptScore W2039626364C2779292878 @default.
- W2039626364 hasConceptScore W2039626364C2781182431 @default.
- W2039626364 hasConceptScore W2039626364C48900799 @default.
- W2039626364 hasConceptScore W2039626364C54355233 @default.
- W2039626364 hasConceptScore W2039626364C553184892 @default.
- W2039626364 hasConceptScore W2039626364C71924100 @default.
- W2039626364 hasConceptScore W2039626364C86803240 @default.
- W2039626364 hasConceptScore W2039626364C90924648 @default.
- W2039626364 hasIssue "4" @default.
- W2039626364 hasLocation W20396263641 @default.
- W2039626364 hasLocation W20396263642 @default.
- W2039626364 hasOpenAccess W2039626364 @default.
- W2039626364 hasPrimaryLocation W20396263641 @default.
- W2039626364 hasRelatedWork W1590578494 @default.
- W2039626364 hasRelatedWork W1734064176 @default.
- W2039626364 hasRelatedWork W1855101007 @default.
- W2039626364 hasRelatedWork W2033978778 @default.
- W2039626364 hasRelatedWork W2376684597 @default.
- W2039626364 hasRelatedWork W2380167350 @default.
- W2039626364 hasRelatedWork W2418297000 @default.
- W2039626364 hasRelatedWork W2444487170 @default.
- W2039626364 hasRelatedWork W4420268 @default.
- W2039626364 hasRelatedWork W2189857467 @default.
- W2039626364 hasVolume "60" @default.
- W2039626364 isParatext "false" @default.
- W2039626364 isRetracted "false" @default.
- W2039626364 magId "2039626364" @default.
- W2039626364 workType "article" @default.