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- W2039650869 abstract "T cell receptor β-chain gene rearrangements were examined in myelin basic protein (MBP)-reactive T cell lines and hybridomas from Lewis (Lew) rats. Nearly 75% of the cloned hybrids were specific for the major encephalitogenic determinant residues 68–88 of guinea pig (GP) MBP; three fine specificities could be distinguished. Southern blot analysis of receptor β-chain genes revealed polyclonality and shared rearrangements not seen in non-68–88-specific clones. Generation of short-term, encephalitogenic Lew T cell lines revealed rearrangements shared with the 68–88-specific hybrids, indicating that the hybrids were representative of the whole antigen-specific population and suggesting restricted Vβ gene usage within this polyclonal population." @default.
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- W2039650869 date "1988-09-01" @default.
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- W2039650869 title "The autoreactive T cell population in experimental allergic encephalomyelitis: T cell receptor β-chain rearrangements" @default.
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- W2039650869 doi "https://doi.org/10.1016/0165-5728(88)90002-1" @default.
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