FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039651630> ?p ?o ?g. }

• W2039651630 endingPage "2734" @default.
• W2039651630 startingPage "2728" @default.
• W2039651630 abstract "The RNA component of the signal recognition particle (SRP) is universally required for cotranslational protein targeting. Biochemical studies have shown that SRP RNA participates in the central step of protein targeting by catalyzing the interaction of the SRP with the SRP receptor (SR). SRP RNA also accelerates GTP hydrolysis in the SRP.SR complex once formed. Using a reverse-genetic and biochemical analysis, we identified mutations in the E. coli SRP protein, Ffh, that abrogate the activity of the SRP RNA and cause corresponding targeting defects in vivo. The mutations in Ffh that disrupt SRP RNA activity map to regions that undergo dramatic conformational changes during the targeting reaction, suggesting that the activity of the SRP RNA is linked to the major conformational changes in the signal sequence-binding subunit of the SRP. In this way, the SRP RNA may coordinate the interaction of the SRP and the SR with ribosome recruitment and transfer to the translocon, explaining why the SRP RNA is an indispensable component of the protein targeting machinery." @default.
• W2039651630 created "2016-06-24" @default.
• W2039651630 creator A5040122426 @default.
• W2039651630 creator A5087493059 @default.
• W2039651630 date "2007-07-01" @default.
• W2039651630 modified "2023-10-11" @default.
• W2039651630 title "The Signal Recognition Particle (SRP) RNA Links Conformational Changes in the SRP to Protein Targeting" @default.
• W2039651630 cites W1976880811 @default.
• W2039651630 cites W1984827214 @default.
• W2039651630 cites W1991467177 @default.
• W2039651630 cites W1994095191 @default.
• W2039651630 cites W1995153766 @default.
• W2039651630 cites W1996489229 @default.
• W2039651630 cites W2000023769 @default.
• W2039651630 cites W2001977025 @default.
• W2039651630 cites W2004538909 @default.
• W2039651630 cites W2009119310 @default.
• W2039651630 cites W2015482548 @default.
• W2039651630 cites W2028386037 @default.
• W2039651630 cites W2037780433 @default.
• W2039651630 cites W2041781518 @default.
• W2039651630 cites W2045032671 @default.
• W2039651630 cites W2050154932 @default.
• W2039651630 cites W2054707540 @default.
• W2039651630 cites W2061492608 @default.
• W2039651630 cites W2067237172 @default.
• W2039651630 cites W2075046123 @default.
• W2039651630 cites W2080821333 @default.
• W2039651630 cites W2090030959 @default.
• W2039651630 cites W2092076365 @default.
• W2039651630 cites W2095509404 @default.
• W2039651630 cites W2100266163 @default.
• W2039651630 cites W2108708484 @default.
• W2039651630 cites W2116687207 @default.
• W2039651630 cites W2119710091 @default.
• W2039651630 cites W2130032853 @default.
• W2039651630 cites W2132629607 @default.
• W2039651630 cites W2136277418 @default.
• W2039651630 cites W2137032962 @default.
• W2039651630 cites W2138438888 @default.
• W2039651630 cites W2138563074 @default.
• W2039651630 cites W2139132736 @default.
• W2039651630 cites W2140139924 @default.
• W2039651630 cites W2153134143 @default.
• W2039651630 cites W2170813053 @default.
• W2039651630 cites W4232524617 @default.
• W2039651630 doi "https://doi.org/10.1091/mbc.e07-02-0117" @default.
• W2039651630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1924838" @default.
• W2039651630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17507650" @default.
• W2039651630 hasPublicationYear "2007" @default.
• W2039651630 type Work @default.
• W2039651630 sameAs 2039651630 @default.
• W2039651630 citedByCount "35" @default.
• W2039651630 countsByYear W20396516302012 @default.
• W2039651630 countsByYear W20396516302013 @default.
• W2039651630 countsByYear W20396516302014 @default.
• W2039651630 countsByYear W20396516302018 @default.
• W2039651630 countsByYear W20396516302020 @default.
• W2039651630 countsByYear W20396516302021 @default.
• W2039651630 countsByYear W20396516302022 @default.
• W2039651630 crossrefType "journal-article" @default.
• W2039651630 hasAuthorship W2039651630A5040122426 @default.
• W2039651630 hasAuthorship W2039651630A5087493059 @default.
• W2039651630 hasBestOaLocation W20396516302 @default.
• W2039651630 hasConcept C104292427 @default.
• W2039651630 hasConcept C104317684 @default.
• W2039651630 hasConcept C105580179 @default.
• W2039651630 hasConcept C138626823 @default.
• W2039651630 hasConcept C144647389 @default.
• W2039651630 hasConcept C149364088 @default.
• W2039651630 hasConcept C186175293 @default.
• W2039651630 hasConcept C199229279 @default.
• W2039651630 hasConcept C203900970 @default.
• W2039651630 hasConcept C36457064 @default.
• W2039651630 hasConcept C41282012 @default.
• W2039651630 hasConcept C41625074 @default.
• W2039651630 hasConcept C55493867 @default.
• W2039651630 hasConcept C559089031 @default.
• W2039651630 hasConcept C67705224 @default.
• W2039651630 hasConcept C86803240 @default.
• W2039651630 hasConcept C88478588 @default.
• W2039651630 hasConcept C95444343 @default.
• W2039651630 hasConceptScore W2039651630C104292427 @default.
• W2039651630 hasConceptScore W2039651630C104317684 @default.
• W2039651630 hasConceptScore W2039651630C105580179 @default.
• W2039651630 hasConceptScore W2039651630C138626823 @default.
• W2039651630 hasConceptScore W2039651630C144647389 @default.
• W2039651630 hasConceptScore W2039651630C149364088 @default.
• W2039651630 hasConceptScore W2039651630C186175293 @default.
• W2039651630 hasConceptScore W2039651630C199229279 @default.
• W2039651630 hasConceptScore W2039651630C203900970 @default.
• W2039651630 hasConceptScore W2039651630C36457064 @default.
• W2039651630 hasConceptScore W2039651630C41282012 @default.
• W2039651630 hasConceptScore W2039651630C41625074 @default.
• W2039651630 hasConceptScore W2039651630C55493867 @default.
• W2039651630 hasConceptScore W2039651630C559089031 @default.
• W2039651630 hasConceptScore W2039651630C67705224 @default.
• W2039651630 hasConceptScore W2039651630C86803240 @default.

• next