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• W2039654416 abstract "Exposure in utero to the synthetic estrogen diethylstilbestrol (DES) is associated with the subsequent development of reproductive-tract malignancies in female offspring. To search for the genetic targets of DES, representational difference analysis was used to compare genomic DNA from DES-associated mouse uterine adenocarcinoma cells with genomic DNA from normal CD-1 mouse tissue. Several difference clones were obtained, all of which recognized rearranged and amplified sequences in tumor compared with normal DNA. One of these difference fragments mapped to a region of mouse chromosome 10 that includes the mdm2 oncogene. Amplification and overexpression of mdm2 was found in all three early-passage cell lines established from independent DES-associated cancers. These findings demonstrate the potential power of representational difference analysis in cancer research and suggest a genetic mechanism for DES-induced carcinogenesis. ©1994 Wiley-Liss, Inc." @default.
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• W2039654416 date "1994-09-01" @default.
• W2039654416 modified "2023-10-10" @default.
• W2039654416 title "Use of representational difference analysis for the identification ofmdm2 oncogene amplification in diethylstilbestrol-induced murine uterine adenocarcinomas" @default.
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• W2039654416 doi "https://doi.org/10.1002/mc.2940110104" @default.
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