Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039673714> ?p ?o ?g. }
- W2039673714 endingPage "558" @default.
- W2039673714 startingPage "543" @default.
- W2039673714 abstract "Cytomegalovirus (CMV) infection is a major cause of morbidity and mortality after hematopoietic stem cell transplantation. Significant progress has been made in the prevention of CMV disease over the past decade, but prevention of late CMV disease continues to be a challenge in selected high-risk populations. The pretransplantation CMV serostatus of the donor and/or recipient remains an important risk factor for posttransplantation outcome despite the use of antiviral prophylaxis and preemptive therapy; CMV-seropositive recipients of T cell-depleted grafts in particular continue to have a survival disadvantage compared with seronegative recipients with seronegative donors. The risk of developing antiviral drug resistance remains low in most patients; however, in a setting of intense immunosuppression (eg, after transplantation from a haploidentical donor), the incidence may be as high as 8%. Primary CMV infection via blood transfusion can be reduced by the provision of seronegative or leukocyte-depleted blood products; however, a small risk of 1% to 2% of CMV disease remains. Surveillance and preemptive therapy are effective in preventing the sequelae of transfusion-related CMV infection. Indirect immunomodulatory effects of CMV are increasingly recognized in hematopoietic stem cell transplant recipients. Strategies currently being investigated include long-term suppression of CMV with valganciclovir for the prevention of late CMV infection and disease, adoptive transfer of CMV-specific T cells, and donor and recipient vaccination strategies." @default.
- W2039673714 created "2016-06-24" @default.
- W2039673714 creator A5001898266 @default.
- W2039673714 creator A5012022936 @default.
- W2039673714 creator A5038572943 @default.
- W2039673714 creator A5061721634 @default.
- W2039673714 creator A5079087824 @default.
- W2039673714 creator A5085442276 @default.
- W2039673714 date "2003-09-01" @default.
- W2039673714 modified "2023-10-01" @default.
- W2039673714 title "Cytomegalovirus in hematopoietic stem cell transplant recipients: current status, known challenges, and future strategies" @default.
- W2039673714 cites W1025463489 @default.
- W2039673714 cites W1564109452 @default.
- W2039673714 cites W1568041502 @default.
- W2039673714 cites W1955863325 @default.
- W2039673714 cites W1964832933 @default.
- W2039673714 cites W1966574164 @default.
- W2039673714 cites W1967480818 @default.
- W2039673714 cites W1974842239 @default.
- W2039673714 cites W1979037054 @default.
- W2039673714 cites W1985591067 @default.
- W2039673714 cites W1986353555 @default.
- W2039673714 cites W1989307686 @default.
- W2039673714 cites W1991121775 @default.
- W2039673714 cites W1993311197 @default.
- W2039673714 cites W1996791121 @default.
- W2039673714 cites W1999847965 @default.
- W2039673714 cites W2008262167 @default.
- W2039673714 cites W2014352019 @default.
- W2039673714 cites W2017025205 @default.
- W2039673714 cites W2017712334 @default.
- W2039673714 cites W2019248811 @default.
- W2039673714 cites W2025383600 @default.
- W2039673714 cites W2032353171 @default.
- W2039673714 cites W2034262274 @default.
- W2039673714 cites W2034740985 @default.
- W2039673714 cites W2035968848 @default.
- W2039673714 cites W2038099344 @default.
- W2039673714 cites W2040396495 @default.
- W2039673714 cites W2040862465 @default.
- W2039673714 cites W2041959641 @default.
- W2039673714 cites W2054364001 @default.
- W2039673714 cites W2059937450 @default.
- W2039673714 cites W2060228686 @default.
- W2039673714 cites W2060484509 @default.
- W2039673714 cites W2061974719 @default.
- W2039673714 cites W2063945161 @default.
- W2039673714 cites W2065623627 @default.
- W2039673714 cites W2066276445 @default.
- W2039673714 cites W2076919967 @default.
- W2039673714 cites W2078419330 @default.
- W2039673714 cites W2078790776 @default.
- W2039673714 cites W2080460977 @default.
- W2039673714 cites W2088315315 @default.
- W2039673714 cites W2090145345 @default.
- W2039673714 cites W2091704657 @default.
- W2039673714 cites W2096233660 @default.
- W2039673714 cites W2099400163 @default.
- W2039673714 cites W2101983446 @default.
- W2039673714 cites W2102083076 @default.
- W2039673714 cites W2102382286 @default.
- W2039673714 cites W2105292098 @default.
- W2039673714 cites W2107412758 @default.
- W2039673714 cites W2110927467 @default.
- W2039673714 cites W2112067138 @default.
- W2039673714 cites W2112300621 @default.
- W2039673714 cites W2117730045 @default.
- W2039673714 cites W2118790191 @default.
- W2039673714 cites W2119393764 @default.
- W2039673714 cites W2119627739 @default.
- W2039673714 cites W2123320255 @default.
- W2039673714 cites W2126499326 @default.
- W2039673714 cites W2126893788 @default.
- W2039673714 cites W2131091524 @default.
- W2039673714 cites W2131394474 @default.
- W2039673714 cites W2133511703 @default.
- W2039673714 cites W2134568690 @default.
- W2039673714 cites W2136497987 @default.
- W2039673714 cites W2143454505 @default.
- W2039673714 cites W2144512751 @default.
- W2039673714 cites W2146259492 @default.
- W2039673714 cites W2146446395 @default.
- W2039673714 cites W2147980413 @default.
- W2039673714 cites W2148242719 @default.
- W2039673714 cites W2161978349 @default.
- W2039673714 cites W2162496953 @default.
- W2039673714 cites W2164143794 @default.
- W2039673714 cites W2164200647 @default.
- W2039673714 cites W2167351117 @default.
- W2039673714 cites W2168046861 @default.
- W2039673714 cites W2169086958 @default.
- W2039673714 cites W2283064218 @default.
- W2039673714 cites W2288682663 @default.
- W2039673714 cites W2315098267 @default.
- W2039673714 cites W2315851568 @default.
- W2039673714 cites W2324172217 @default.
- W2039673714 cites W2327389456 @default.
- W2039673714 cites W2335329602 @default.