Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039677112> ?p ?o ?g. }
- W2039677112 endingPage "347" @default.
- W2039677112 startingPage "338" @default.
- W2039677112 abstract "Varicella zoster virus (VZV) is recognized as one of the major viral pathogens reactivated in patients with the acquired immune deficiency syndrome (AIDS). We report the case of meningoradiculoneuritis in an AIDS patient,associated with the isolation in the cerebrospinal fluid (CSF) of a thymidine kinase (TK)-deficient, acyclovir (ACV)-resistant strain of VZV. Although the virus was sensitive in vitro to phosphonoformate (PFA), the patient did not improve during PFA therapy and finally died. Several VZV strains isolated from this patient (including two isolates from the patient's CSF) were analyzed for their TK activity and subsequently the viral TK gene was sequenced showing a major deletion leading to a truncated protein. Their susceptibility to several antiviral agents including ACV, PFA, (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU), 9-beta-D-arabinofuranosyladenine (vidarabine), (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine (HPMPC), and (S)-9-(3-hydroxy-2-phosphonyl-methoxypropyl)adenine (HPMPA) was evaluated. All the virus strains isolated from this patient remained sensitive to HPMPA and HPMPC, pointing to the potential usefulness of these acyclic nucleoside phosphonates for the treatment of ACV-resistant VZV infections in immunocompromised patients." @default.
- W2039677112 created "2016-06-24" @default.
- W2039677112 creator A5020339223 @default.
- W2039677112 creator A5029972124 @default.
- W2039677112 creator A5030479730 @default.
- W2039677112 creator A5033714637 @default.
- W2039677112 creator A5034473483 @default.
- W2039677112 creator A5038319371 @default.
- W2039677112 creator A5040662398 @default.
- W2039677112 creator A5042823176 @default.
- W2039677112 creator A5067400955 @default.
- W2039677112 creator A5073574070 @default.
- W2039677112 creator A5073911822 @default.
- W2039677112 creator A5085228034 @default.
- W2039677112 date "1994-04-01" @default.
- W2039677112 modified "2023-09-26" @default.
- W2039677112 title "Meningoradiculoneuritis due to acyclovir-resistant varicella zoster virus in an acquired immune deficiency syndrome patient" @default.
- W2039677112 cites W1495901994 @default.
- W2039677112 cites W1496381510 @default.
- W2039677112 cites W1514278476 @default.
- W2039677112 cites W1582367115 @default.
- W2039677112 cites W1888686964 @default.
- W2039677112 cites W1900763607 @default.
- W2039677112 cites W1972241043 @default.
- W2039677112 cites W1978095447 @default.
- W2039677112 cites W1984880755 @default.
- W2039677112 cites W1986052834 @default.
- W2039677112 cites W1992036604 @default.
- W2039677112 cites W1997285921 @default.
- W2039677112 cites W2000565605 @default.
- W2039677112 cites W2001045655 @default.
- W2039677112 cites W2006114695 @default.
- W2039677112 cites W2009635628 @default.
- W2039677112 cites W2012544930 @default.
- W2039677112 cites W2017686017 @default.
- W2039677112 cites W2022051536 @default.
- W2039677112 cites W2039623414 @default.
- W2039677112 cites W2047650206 @default.
- W2039677112 cites W2059286898 @default.
- W2039677112 cites W2062983318 @default.
- W2039677112 cites W2063466305 @default.
- W2039677112 cites W2063651869 @default.
- W2039677112 cites W2063891096 @default.
- W2039677112 cites W2069816948 @default.
- W2039677112 cites W2072462608 @default.
- W2039677112 cites W2084785749 @default.
- W2039677112 cites W2107380406 @default.
- W2039677112 cites W2119697009 @default.
- W2039677112 cites W2137222688 @default.
- W2039677112 cites W2137562741 @default.
- W2039677112 cites W2138495777 @default.
- W2039677112 cites W2140415704 @default.
- W2039677112 cites W2145090218 @default.
- W2039677112 cites W2317173197 @default.
- W2039677112 cites W2318959418 @default.
- W2039677112 cites W2334496954 @default.
- W2039677112 cites W2337397650 @default.
- W2039677112 cites W2338795352 @default.
- W2039677112 cites W2466191519 @default.
- W2039677112 cites W4240627419 @default.
- W2039677112 cites W4366956072 @default.
- W2039677112 doi "https://doi.org/10.1002/jmv.1890420404" @default.
- W2039677112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8046424" @default.
- W2039677112 hasPublicationYear "1994" @default.
- W2039677112 type Work @default.
- W2039677112 sameAs 2039677112 @default.
- W2039677112 citedByCount "54" @default.
- W2039677112 countsByYear W20396771122012 @default.
- W2039677112 countsByYear W20396771122013 @default.
- W2039677112 countsByYear W20396771122017 @default.
- W2039677112 countsByYear W20396771122019 @default.
- W2039677112 countsByYear W20396771122020 @default.
- W2039677112 countsByYear W20396771122021 @default.
- W2039677112 crossrefType "journal-article" @default.
- W2039677112 hasAuthorship W2039677112A5020339223 @default.
- W2039677112 hasAuthorship W2039677112A5029972124 @default.
- W2039677112 hasAuthorship W2039677112A5030479730 @default.
- W2039677112 hasAuthorship W2039677112A5033714637 @default.
- W2039677112 hasAuthorship W2039677112A5034473483 @default.
- W2039677112 hasAuthorship W2039677112A5038319371 @default.
- W2039677112 hasAuthorship W2039677112A5040662398 @default.
- W2039677112 hasAuthorship W2039677112A5042823176 @default.
- W2039677112 hasAuthorship W2039677112A5067400955 @default.
- W2039677112 hasAuthorship W2039677112A5073574070 @default.
- W2039677112 hasAuthorship W2039677112A5073911822 @default.
- W2039677112 hasAuthorship W2039677112A5085228034 @default.
- W2039677112 hasConcept C159047783 @default.
- W2039677112 hasConcept C203014093 @default.
- W2039677112 hasConcept C2522874641 @default.
- W2039677112 hasConcept C2776147627 @default.
- W2039677112 hasConcept C2776159415 @default.
- W2039677112 hasConcept C2776409557 @default.
- W2039677112 hasConcept C2776543447 @default.
- W2039677112 hasConcept C2776724271 @default.
- W2039677112 hasConcept C2777333352 @default.
- W2039677112 hasConcept C2779450786 @default.
- W2039677112 hasConcept C2780727368 @default.
- W2039677112 hasConcept C2781196997 @default.