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- W2039686675 abstract "A physiological function of the original uncoupling protein, UCP1, is well established: UCP1 is the molecular background for nonshivering thermogenesis. The functions of the “novel” UCPs, UCP2 and UCP3, are still not established. Recent discussions imply that all UCPs may play a role in protection against reactive oxygen species (ROS). Here we examine critically the evidence that UCP1, UCP2 and UCP3 are stimulated by ROS (superoxide) or ROS products (4-hydroxy-2-nonenal), and that the UCPs actually diminish oxidative damage. We conclude that, concerning UCP1, it is unlikely that it has such a role; concerning UCP2/UCP3, most evidence for physiologically significant roles in this respect is still circumstantial." @default.
- W2039686675 created "2016-06-24" @default.
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- W2039686675 date "2006-05-01" @default.
- W2039686675 modified "2023-10-18" @default.
- W2039686675 title "Uncoupling proteins: A role in protection against reactive oxygen species—or not?" @default.
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- W2039686675 doi "https://doi.org/10.1016/j.bbabio.2006.05.016" @default.
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