FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039687615> ?p ?o ?g. }

• W2039687615 endingPage "101" @default.
• W2039687615 startingPage "87" @default.
• W2039687615 abstract "The presentation of antigen to specific T-cell populations is a crucial event during the elicitation phase of contact hypersensitivity (CHS). Significant changes in CD4(+) T-cell and gammadelta T-cell populations occur in the skin of sheep 48h after re-exposure to dinitrochlorobenzene but the expression of antigen presentation molecules such as MHC-II and CD1 at this stage of the hypersensitivity response has not been investigated. In the present study, a panel of monoclonal antibodies recognising CD1 and MHC-II subtypes was used in combination with computer assisted morphometric analysis to estimate the distribution of antigen presentation molecules in the superficial and deep dermis of the ears of lambs during the elicitation phase of CHS. The MHC-II molecules showed predominantly a perivascular and peri-appendageal distribution in the dermis and there were scattered MHC-II(+) cells in the basal and suprabasal layers of the epidermis. The CD1w2(+) (CD1b-like) molecules were present on distinct cells that were scattered evenly through the dermis, whereas CD1w3(+) (CD1c-like) molecules were almost exclusively detected on or in close association with the vascular endothelium. There was a significant increase in the presence of MHC-DQ(+) cells in the superficial dermis of dinitrochlorobenzene-treated animals compared with both an untreated control group and a vehicle-treated control group. However, MHC-DQ/DR(+) and CD1w3(+) cells only showed a significant increase compared with the vehicle-treated control group. The present study shows that the distribution of molecules involved in antigen presentation to CD4(+) T-cells and gammadelta T-cells changes during the elicitation phase of CHS in sheep, and suggests a role for MHC-DQ molecules on antigen presenting cells. However, the changes in distribution and expression of MHC-II and CD1 subtypes argue against a prominent role for a CD1-dependent pathway for T-cell recognition in the clinical cutaneous hypersensitivity response in sheep. Based on the expression of MHC-II molecules and CD1c molecules, we also suggest a potential role for endothelial cells in antigen presentation during the clinical dermatitis reaction." @default.
• W2039687615 created "2016-06-24" @default.
• W2039687615 creator A5008497641 @default.
• W2039687615 creator A5045606213 @default.
• W2039687615 creator A5074027197 @default.
• W2039687615 date "2000-04-01" @default.
• W2039687615 modified "2023-09-27" @default.
• W2039687615 title "Distribution of MHC-II and CD1 molecules in the skin of lambs and changes during experimentally-induced contact hypersensitivity" @default.
• W2039687615 cites W1766534957 @default.
• W2039687615 cites W1967692350 @default.
• W2039687615 cites W1970285388 @default.
• W2039687615 cites W1974822381 @default.
• W2039687615 cites W1975931186 @default.
• W2039687615 cites W1977918150 @default.
• W2039687615 cites W1980554277 @default.
• W2039687615 cites W1981619953 @default.
• W2039687615 cites W1985849850 @default.
• W2039687615 cites W1985851704 @default.
• W2039687615 cites W1988096235 @default.
• W2039687615 cites W1992587784 @default.
• W2039687615 cites W1994831601 @default.
• W2039687615 cites W1997541304 @default.
• W2039687615 cites W2007737562 @default.
• W2039687615 cites W2010867882 @default.
• W2039687615 cites W2011574541 @default.
• W2039687615 cites W2017020925 @default.
• W2039687615 cites W2018776087 @default.
• W2039687615 cites W2020807076 @default.
• W2039687615 cites W2022563109 @default.
• W2039687615 cites W2025854229 @default.
• W2039687615 cites W2043158677 @default.
• W2039687615 cites W2043748369 @default.
• W2039687615 cites W2046904513 @default.
• W2039687615 cites W2049868430 @default.
• W2039687615 cites W2068213448 @default.
• W2039687615 cites W2074926840 @default.
• W2039687615 cites W2080380312 @default.
• W2039687615 cites W2080701518 @default.
• W2039687615 cites W2088563489 @default.
• W2039687615 cites W2091198741 @default.
• W2039687615 cites W2091283829 @default.
• W2039687615 cites W2096647640 @default.
• W2039687615 cites W2118966648 @default.
• W2039687615 cites W2123223407 @default.
• W2039687615 cites W2128708262 @default.
• W2039687615 cites W2157951282 @default.
• W2039687615 cites W2168176735 @default.
• W2039687615 doi "https://doi.org/10.1016/s0165-2427(00)00169-0" @default.
• W2039687615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10760392" @default.
• W2039687615 hasPublicationYear "2000" @default.
• W2039687615 type Work @default.
• W2039687615 sameAs 2039687615 @default.
• W2039687615 citedByCount "3" @default.
• W2039687615 crossrefType "journal-article" @default.
• W2039687615 hasAuthorship W2039687615A5008497641 @default.
• W2039687615 hasAuthorship W2039687615A5045606213 @default.
• W2039687615 hasAuthorship W2039687615A5074027197 @default.
• W2039687615 hasConcept C105702510 @default.
• W2039687615 hasConcept C139563560 @default.
• W2039687615 hasConcept C147483822 @default.
• W2039687615 hasConcept C153911025 @default.
• W2039687615 hasConcept C167672396 @default.
• W2039687615 hasConcept C170627219 @default.
• W2039687615 hasConcept C203014093 @default.
• W2039687615 hasConcept C207936829 @default.
• W2039687615 hasConcept C2776090121 @default.
• W2039687615 hasConcept C2776458125 @default.
• W2039687615 hasConcept C2777624698 @default.
• W2039687615 hasConcept C2778814158 @default.
• W2039687615 hasConcept C37386791 @default.
• W2039687615 hasConcept C83464605 @default.
• W2039687615 hasConcept C86803240 @default.
• W2039687615 hasConcept C8891405 @default.
• W2039687615 hasConceptScore W2039687615C105702510 @default.
• W2039687615 hasConceptScore W2039687615C139563560 @default.
• W2039687615 hasConceptScore W2039687615C147483822 @default.
• W2039687615 hasConceptScore W2039687615C153911025 @default.
• W2039687615 hasConceptScore W2039687615C167672396 @default.
• W2039687615 hasConceptScore W2039687615C170627219 @default.
• W2039687615 hasConceptScore W2039687615C203014093 @default.
• W2039687615 hasConceptScore W2039687615C207936829 @default.
• W2039687615 hasConceptScore W2039687615C2776090121 @default.
• W2039687615 hasConceptScore W2039687615C2776458125 @default.
• W2039687615 hasConceptScore W2039687615C2777624698 @default.
• W2039687615 hasConceptScore W2039687615C2778814158 @default.
• W2039687615 hasConceptScore W2039687615C37386791 @default.
• W2039687615 hasConceptScore W2039687615C83464605 @default.
• W2039687615 hasConceptScore W2039687615C86803240 @default.
• W2039687615 hasConceptScore W2039687615C8891405 @default.
• W2039687615 hasIssue "1-2" @default.
• W2039687615 hasLocation W20396876151 @default.
• W2039687615 hasLocation W20396876152 @default.
• W2039687615 hasOpenAccess W2039687615 @default.
• W2039687615 hasPrimaryLocation W20396876151 @default.
• W2039687615 hasRelatedWork W1562706914 @default.
• W2039687615 hasRelatedWork W1606425948 @default.
• W2039687615 hasRelatedWork W1665569308 @default.
• W2039687615 hasRelatedWork W1982805017 @default.

• next