FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039690384> ?p ?o ?g. }

• W2039690384 endingPage "1424" @default.
• W2039690384 startingPage "1415" @default.
• W2039690384 abstract "Loss of heterozygosity (LOH) of chromosome 1 has been suggested, by karyotyping, to be an initial episode in human hepatocarcinogenesis. However, this alteration has not yet been investigated in cirrhotic nodules (CNs) or dysplastic nodules (DNs). In an initial study from explanted or resected cirrhotic livers, LOH in 1p36-p32 was examined in 31 hepatocellular carcinomas (HCCs), 25 low-grade dysplastic nodules (LGDNs), and 24 high-grade dysplastic nodules (HGDNs). In HCCs, LOH was detected most frequently at loci D1S2843 (1p36.1) (28.6%), D1S513 (1p34.3) (29.2%), and MYCL1 (1p34.1) (28.6%). In HGDN and LGDN, LOH incidences at D1S513 were 11.1% and 13.6%, respectively. To further refine those results and to determine sequential relationships among CN, DN, and HCC, LOH was next studied in an additional 53 HCCs, 56 HGDNs, 30 LGDNs, and 215 CNs from 11 explanted human cirrhotic livers, including 30 “nodule-in-nodule” lesions. Seven markers between D1S2843 (1p36.12) and MYCL1 (1p34.1), and 1 each at D1S484 (1q24.1), IGF2R-3 (6q26), and TP53 (17p13.1) were used. LOH at D1S2843 and D1S513 was detected in HCCs (20.4% and 23.5%, respectively), HGDNs (7.7% and 18.5%), LGDNs (13.6% and 6.9%), and CNs surrounding either HCCs or DNs (7.4% and 8.3%). These results demonstrate that LOH at D1S2843 and D1S513 are early events in human liver carcinogenesis. Data from CN surrounding either HCCs or DN, and also nodule-in-nodule lesions, provide evidence supporting a CN→DN→HCC progression. Different deletion patterns from multiple HCCs and DNs suggest independent origins for carcinogenesis in the same individual." @default.
• W2039690384 created "2016-06-24" @default.
• W2039690384 creator A5032150468 @default.
• W2039690384 creator A5036272746 @default.
• W2039690384 creator A5037203912 @default.
• W2039690384 creator A5056390248 @default.
• W2039690384 creator A5058699357 @default.
• W2039690384 creator A5059832377 @default.
• W2039690384 creator A5079854745 @default.
• W2039690384 creator A5081590732 @default.
• W2039690384 date "2001-06-01" @default.
• W2039690384 modified "2023-10-17" @default.
• W2039690384 title "An early lesion in hepatic carcinogenesis: Loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region" @default.
• W2039690384 cites W1585869774 @default.
• W2039690384 cites W1845252930 @default.
• W2039690384 cites W1967917844 @default.
• W2039690384 cites W1975702434 @default.
• W2039690384 cites W1975884873 @default.
• W2039690384 cites W1983637619 @default.
• W2039690384 cites W1988407960 @default.
• W2039690384 cites W1991949008 @default.
• W2039690384 cites W1992732611 @default.
• W2039690384 cites W2009752621 @default.
• W2039690384 cites W2033140234 @default.
• W2039690384 cites W2047692862 @default.
• W2039690384 cites W2058579700 @default.
• W2039690384 cites W2066180821 @default.
• W2039690384 cites W2069505491 @default.
• W2039690384 cites W2070652828 @default.
• W2039690384 cites W2075544982 @default.
• W2039690384 cites W2079186794 @default.
• W2039690384 cites W2083771640 @default.
• W2039690384 cites W2100451215 @default.
• W2039690384 cites W2100763940 @default.
• W2039690384 cites W2108683988 @default.
• W2039690384 cites W2112781520 @default.
• W2039690384 cites W2122974780 @default.
• W2039690384 cites W2128452400 @default.
• W2039690384 cites W2134153682 @default.
• W2039690384 cites W2141759099 @default.
• W2039690384 cites W2142248814 @default.
• W2039690384 cites W2143950916 @default.
• W2039690384 cites W2151530333 @default.
• W2039690384 cites W2177344829 @default.
• W2039690384 cites W2397932901 @default.
• W2039690384 cites W2409212094 @default.
• W2039690384 cites W2413593401 @default.
• W2039690384 cites W2471463621 @default.
• W2039690384 cites W2891666490 @default.
• W2039690384 doi "https://doi.org/10.1053/jhep.2001.24751" @default.
• W2039690384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11391530" @default.
• W2039690384 hasPublicationYear "2001" @default.
• W2039690384 type Work @default.
• W2039690384 sameAs 2039690384 @default.
• W2039690384 citedByCount "58" @default.
• W2039690384 countsByYear W20396903842012 @default.
• W2039690384 countsByYear W20396903842013 @default.
• W2039690384 countsByYear W20396903842014 @default.
• W2039690384 countsByYear W20396903842015 @default.
• W2039690384 countsByYear W20396903842016 @default.
• W2039690384 countsByYear W20396903842017 @default.
• W2039690384 countsByYear W20396903842018 @default.
• W2039690384 crossrefType "journal-article" @default.
• W2039690384 hasAuthorship W2039690384A5032150468 @default.
• W2039690384 hasAuthorship W2039690384A5036272746 @default.
• W2039690384 hasAuthorship W2039690384A5037203912 @default.
• W2039690384 hasAuthorship W2039690384A5056390248 @default.
• W2039690384 hasAuthorship W2039690384A5058699357 @default.
• W2039690384 hasAuthorship W2039690384A5059832377 @default.
• W2039690384 hasAuthorship W2039690384A5079854745 @default.
• W2039690384 hasAuthorship W2039690384A5081590732 @default.
• W2039690384 hasBestOaLocation W20396903841 @default.
• W2039690384 hasConcept C104317684 @default.
• W2039690384 hasConcept C121608353 @default.
• W2039690384 hasConcept C142724271 @default.
• W2039690384 hasConcept C143589142 @default.
• W2039690384 hasConcept C151730666 @default.
• W2039690384 hasConcept C180754005 @default.
• W2039690384 hasConcept C2776731575 @default.
• W2039690384 hasConcept C2778019345 @default.
• W2039690384 hasConcept C2779314089 @default.
• W2039690384 hasConcept C2781156865 @default.
• W2039690384 hasConcept C502942594 @default.
• W2039690384 hasConcept C54355233 @default.
• W2039690384 hasConcept C555283112 @default.
• W2039690384 hasConcept C71924100 @default.
• W2039690384 hasConcept C86803240 @default.
• W2039690384 hasConceptScore W2039690384C104317684 @default.
• W2039690384 hasConceptScore W2039690384C121608353 @default.
• W2039690384 hasConceptScore W2039690384C142724271 @default.
• W2039690384 hasConceptScore W2039690384C143589142 @default.
• W2039690384 hasConceptScore W2039690384C151730666 @default.
• W2039690384 hasConceptScore W2039690384C180754005 @default.
• W2039690384 hasConceptScore W2039690384C2776731575 @default.
• W2039690384 hasConceptScore W2039690384C2778019345 @default.
• W2039690384 hasConceptScore W2039690384C2779314089 @default.
• W2039690384 hasConceptScore W2039690384C2781156865 @default.
• W2039690384 hasConceptScore W2039690384C502942594 @default.

• next