FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039692007> ?p ?o ?g. }

• W2039692007 endingPage "317" @default.
• W2039692007 startingPage "311" @default.
• W2039692007 abstract "To investigate intercellular compartmentation of liver metabolism, we have recently introduced new procedures for quantitative assessment of metabolic liver cell heterogeneity both along sinusoids of portal and septal origins as well as at the level of the parenchymal unit, and also for three-dimensional imaging of enzyme and metabolite distribution. As part of the evaluation of the role of metabolic liver cell heterogeneity for the regulation of net substrate flux in the glucose-6-phosphatase/glucokinase system, and for the reduction of glucose/glucose-6-P recycling through spatial separation of these antagonistic enzymes, these techniques were used on livers from male rats. They served to obtain distribution data on glucose-6-phosphatase (the hydrolytic component of the glucose-6-phosphatase/glucokinase system) and its substrate, glucose-6-P, during the postresorptive phase (i.e., a metabolic state of net glucose release). Glucose-6-phosphatase (Vmax) and glucose-6-P were shown to decrease along the sinusoidal axis, and values of both parameters were significantly higher along sinusoids of portal than septal origin. Distribution of in vivo rates of glucose-6-P hydrolysis indicates the importance of metabolite distribution for in vivo regulation of liver cell function, insofar as it considerably increases the degree of heterogeneity among hepatocytes over that of maximal rates of glucose formation. Histo- and microchemical data support the concept of a “lobular parenchymal unit” composed of “primary lobules,” and justify the conclusion that hepatocyte function, in addition to the hormonal and nutritional states of the animal, not only depends upon cell location along the sinusoidal axis, but also on the origin of sinusoids." @default.
• W2039692007 created "2016-06-24" @default.
• W2039692007 creator A5072079966 @default.
• W2039692007 date "1988-03-01" @default.
• W2039692007 modified "2023-10-02" @default.
• W2039692007 title "Regionality of glucose-6-phosphate hydrolysis in the liver lobule of the rat: Metabolic heterogeneity of “portal” and “septal” sinusoids" @default.
• W2039692007 cites W122296119 @default.
• W2039692007 cites W128884300 @default.
• W2039692007 cites W1492547835 @default.
• W2039692007 cites W150236024 @default.
• W2039692007 cites W1507867204 @default.
• W2039692007 cites W1509948152 @default.
• W2039692007 cites W1525588707 @default.
• W2039692007 cites W1526998224 @default.
• W2039692007 cites W1592768658 @default.
• W2039692007 cites W1815598565 @default.
• W2039692007 cites W1823433937 @default.
• W2039692007 cites W1971940397 @default.
• W2039692007 cites W1974514663 @default.
• W2039692007 cites W1977088306 @default.
• W2039692007 cites W1979710760 @default.
• W2039692007 cites W1986500047 @default.
• W2039692007 cites W1986866119 @default.
• W2039692007 cites W2000935965 @default.
• W2039692007 cites W2008572078 @default.
• W2039692007 cites W2014848994 @default.
• W2039692007 cites W2028186728 @default.
• W2039692007 cites W2045659163 @default.
• W2039692007 cites W2071903093 @default.
• W2039692007 cites W2085181720 @default.
• W2039692007 cites W2134883783 @default.
• W2039692007 cites W2160632054 @default.
• W2039692007 cites W2170344388 @default.
• W2039692007 cites W4242846972 @default.
• W2039692007 cites W4243304117 @default.
• W2039692007 cites W2056516859 @default.
• W2039692007 doi "https://doi.org/10.1002/hep.1840080221" @default.
• W2039692007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3356412" @default.
• W2039692007 hasPublicationYear "1988" @default.
• W2039692007 type Work @default.
• W2039692007 sameAs 2039692007 @default.
• W2039692007 citedByCount "39" @default.
• W2039692007 countsByYear W20396920072012 @default.
• W2039692007 countsByYear W20396920072016 @default.
• W2039692007 countsByYear W20396920072018 @default.
• W2039692007 countsByYear W20396920072021 @default.
• W2039692007 crossrefType "journal-article" @default.
• W2039692007 hasAuthorship W2039692007A5072079966 @default.
• W2039692007 hasConcept C126322002 @default.
• W2039692007 hasConcept C134018914 @default.
• W2039692007 hasConcept C150903083 @default.
• W2039692007 hasConcept C17093226 @default.
• W2039692007 hasConcept C181199279 @default.
• W2039692007 hasConcept C185592680 @default.
• W2039692007 hasConcept C202751555 @default.
• W2039692007 hasConcept C207001950 @default.
• W2039692007 hasConcept C2776200302 @default.
• W2039692007 hasConcept C2777477808 @default.
• W2039692007 hasConcept C2778713356 @default.
• W2039692007 hasConcept C2779202576 @default.
• W2039692007 hasConcept C55493867 @default.
• W2039692007 hasConcept C57322979 @default.
• W2039692007 hasConcept C62231903 @default.
• W2039692007 hasConcept C71924100 @default.
• W2039692007 hasConcept C86803240 @default.
• W2039692007 hasConcept C98335778 @default.
• W2039692007 hasConceptScore W2039692007C126322002 @default.
• W2039692007 hasConceptScore W2039692007C134018914 @default.
• W2039692007 hasConceptScore W2039692007C150903083 @default.
• W2039692007 hasConceptScore W2039692007C17093226 @default.
• W2039692007 hasConceptScore W2039692007C181199279 @default.
• W2039692007 hasConceptScore W2039692007C185592680 @default.
• W2039692007 hasConceptScore W2039692007C202751555 @default.
• W2039692007 hasConceptScore W2039692007C207001950 @default.
• W2039692007 hasConceptScore W2039692007C2776200302 @default.
• W2039692007 hasConceptScore W2039692007C2777477808 @default.
• W2039692007 hasConceptScore W2039692007C2778713356 @default.
• W2039692007 hasConceptScore W2039692007C2779202576 @default.
• W2039692007 hasConceptScore W2039692007C55493867 @default.
• W2039692007 hasConceptScore W2039692007C57322979 @default.
• W2039692007 hasConceptScore W2039692007C62231903 @default.
• W2039692007 hasConceptScore W2039692007C71924100 @default.
• W2039692007 hasConceptScore W2039692007C86803240 @default.
• W2039692007 hasConceptScore W2039692007C98335778 @default.
• W2039692007 hasIssue "2" @default.
• W2039692007 hasLocation W20396920071 @default.
• W2039692007 hasLocation W20396920072 @default.
• W2039692007 hasOpenAccess W2039692007 @default.
• W2039692007 hasPrimaryLocation W20396920071 @default.
• W2039692007 hasRelatedWork W1532950599 @default.
• W2039692007 hasRelatedWork W2039692007 @default.
• W2039692007 hasRelatedWork W2041949500 @default.
• W2039692007 hasRelatedWork W2053745886 @default.
• W2039692007 hasRelatedWork W2071777834 @default.
• W2039692007 hasRelatedWork W2111629437 @default.
• W2039692007 hasRelatedWork W2153117421 @default.
• W2039692007 hasRelatedWork W2153296186 @default.
• W2039692007 hasRelatedWork W2156187506 @default.

• next