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• W2039693737 startingPage "e116" @default.
• W2039693737 abstract "Eukaryotic cells possess several mechanisms to protect the integrity of their DNA against damage. These include cell-cycle checkpoints, DNA-repair pathways, and also a distinct DNA damage–tolerance system that allows recovery of replication forks blocked at sites of DNA damage. In both humans and yeast, lesion bypass and restart of DNA synthesis can occur through an error-prone pathway activated following mono-ubiquitination of proliferating cell nuclear antigen (PCNA), a protein found at sites of replication, and recruitment of specialized translesion synthesis polymerases. In yeast, there is evidence for a second, error-free, pathway that requires modification of PCNA with non-proteolytic lysine 63-linked polyubiquitin (K63-polyUb) chains. Here we demonstrate that formation of K63-polyUb chains protects human cells against translesion synthesis–induced mutations by promoting recovery of blocked replication forks through an alternative error-free mechanism. Furthermore, we show that polyubiquitination of PCNA occurs in UV-irradiated human cells. Our findings indicate that K63-polyubiquitination guards against environmental carcinogenesis and contributes to genomic stability." @default.
• W2039693737 created "2016-06-24" @default.
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• W2039693737 date "2006-07-21" @default.
• W2039693737 modified "2023-10-10" @default.
• W2039693737 title "Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations" @default.
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• W2039693737 doi "https://doi.org/10.1371/journal.pgen.0020116" @default.
• W2039693737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1513265" @default.
• W2039693737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16789823" @default.
• W2039693737 hasPublicationYear "2006" @default.
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