Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039694476> ?p ?o ?g. }
- W2039694476 endingPage "4256" @default.
- W2039694476 startingPage "4243" @default.
- W2039694476 abstract "Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. Collagen VI (COL6) is highly expressed in adipose tissue, upregulated in the obese state, and enriched in breast cancer lesions and is a stimulator of mammary tumor growth. Here, we have described a cleavage product of the COL6α3 chain, endotrophin (ETP), which serves as the major mediator of the COL6-mediated tumor effects. ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. Moreover, ETP expression was associated with aggressive mammary tumor growth and high metastatic growth. These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells." @default.
- W2039694476 created "2016-06-24" @default.
- W2039694476 creator A5057094394 @default.
- W2039694476 creator A5077747436 @default.
- W2039694476 date "2012-10-08" @default.
- W2039694476 modified "2023-10-16" @default.
- W2039694476 title "Adipocyte-derived endotrophin promotes malignant tumor progression" @default.
- W2039694476 cites W1964454230 @default.
- W2039694476 cites W1964731186 @default.
- W2039694476 cites W1975514965 @default.
- W2039694476 cites W1975600980 @default.
- W2039694476 cites W1978281808 @default.
- W2039694476 cites W1986557818 @default.
- W2039694476 cites W1988109900 @default.
- W2039694476 cites W1993922189 @default.
- W2039694476 cites W1998780779 @default.
- W2039694476 cites W2009172514 @default.
- W2039694476 cites W2010571055 @default.
- W2039694476 cites W2018211174 @default.
- W2039694476 cites W2028505689 @default.
- W2039694476 cites W2033341544 @default.
- W2039694476 cites W2037099316 @default.
- W2039694476 cites W2055858409 @default.
- W2039694476 cites W2061202791 @default.
- W2039694476 cites W2062265555 @default.
- W2039694476 cites W2062809449 @default.
- W2039694476 cites W2068694666 @default.
- W2039694476 cites W2069533740 @default.
- W2039694476 cites W2076583198 @default.
- W2039694476 cites W2084294927 @default.
- W2039694476 cites W2085957571 @default.
- W2039694476 cites W2089258206 @default.
- W2039694476 cites W2090286224 @default.
- W2039694476 cites W2090339804 @default.
- W2039694476 cites W2091546407 @default.
- W2039694476 cites W2092155461 @default.
- W2039694476 cites W2098034905 @default.
- W2039694476 cites W2100303404 @default.
- W2039694476 cites W2103031848 @default.
- W2039694476 cites W2105156168 @default.
- W2039694476 cites W2106394177 @default.
- W2039694476 cites W2111449140 @default.
- W2039694476 cites W2117692326 @default.
- W2039694476 cites W2122779261 @default.
- W2039694476 cites W2125922121 @default.
- W2039694476 cites W2127734452 @default.
- W2039694476 cites W2129115386 @default.
- W2039694476 cites W2129209927 @default.
- W2039694476 cites W2130064617 @default.
- W2039694476 cites W2136858036 @default.
- W2039694476 cites W2140551998 @default.
- W2039694476 cites W2145323170 @default.
- W2039694476 cites W2153383900 @default.
- W2039694476 cites W2163691580 @default.
- W2039694476 cites W2167451834 @default.
- W2039694476 cites W2804842145 @default.
- W2039694476 cites W4239907137 @default.
- W2039694476 cites W4249727000 @default.
- W2039694476 doi "https://doi.org/10.1172/jci63930" @default.
- W2039694476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3484450" @default.
- W2039694476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23041627" @default.
- W2039694476 hasPublicationYear "2012" @default.
- W2039694476 type Work @default.
- W2039694476 sameAs 2039694476 @default.
- W2039694476 citedByCount "259" @default.
- W2039694476 countsByYear W20396944762012 @default.
- W2039694476 countsByYear W20396944762013 @default.
- W2039694476 countsByYear W20396944762014 @default.
- W2039694476 countsByYear W20396944762015 @default.
- W2039694476 countsByYear W20396944762016 @default.
- W2039694476 countsByYear W20396944762017 @default.
- W2039694476 countsByYear W20396944762018 @default.
- W2039694476 countsByYear W20396944762019 @default.
- W2039694476 countsByYear W20396944762020 @default.
- W2039694476 countsByYear W20396944762021 @default.
- W2039694476 countsByYear W20396944762022 @default.
- W2039694476 countsByYear W20396944762023 @default.
- W2039694476 crossrefType "journal-article" @default.
- W2039694476 hasAuthorship W2039694476A5057094394 @default.
- W2039694476 hasAuthorship W2039694476A5077747436 @default.
- W2039694476 hasBestOaLocation W20396944761 @default.
- W2039694476 hasConcept C121608353 @default.
- W2039694476 hasConcept C126322002 @default.
- W2039694476 hasConcept C134018914 @default.
- W2039694476 hasConcept C16930146 @default.
- W2039694476 hasConcept C171089720 @default.
- W2039694476 hasConcept C2776107976 @default.
- W2039694476 hasConcept C2776175234 @default.
- W2039694476 hasConcept C2776187077 @default.
- W2039694476 hasConcept C2779256057 @default.
- W2039694476 hasConcept C2780394083 @default.
- W2039694476 hasConcept C2780559512 @default.
- W2039694476 hasConcept C3020616263 @default.
- W2039694476 hasConcept C502942594 @default.
- W2039694476 hasConcept C530470458 @default.
- W2039694476 hasConcept C71924100 @default.
- W2039694476 hasConcept C86803240 @default.
- W2039694476 hasConceptScore W2039694476C121608353 @default.