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- W2039697511 endingPage "140162" @default.
- W2039697511 startingPage "140162" @default.
- W2039697511 abstract "Cell cycle progression is regulated by members of the cyclin-dependent kinase (CDK), Polo and Aurora families of protein kinases. The levels of expression and localization of the key regulatory kinases are themselves subject to very tight control. There is increasing evidence that crosstalk between the mitotic kinases provides for an additional level of regulation. We have previously shown that Aurora B activates Polo kinase at the centromere in mitosis, and that the interaction between Polo and the chromosomal passenger complex (CPC) component INCENP is essential in this activation. In this report, we show that Polo kinase is required for the correct localization and activity of the CPC in meiosis and mitosis. Study of the phenotype of different polo allele combinations compared to the effect of chemical inhibition revealed significant differences in the localization and activity of the CPC in diploid tissues. Our results shed new light on the mechanisms that control the activity of Aurora B in meiosis and mitosis." @default.
- W2039697511 created "2016-06-24" @default.
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- W2039697511 date "2014-11-01" @default.
- W2039697511 modified "2023-09-25" @default.
- W2039697511 title "Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in <i>Drosophila melanogaster</i>" @default.
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- W2039697511 doi "https://doi.org/10.1098/rsob.140162" @default.
- W2039697511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4248065" @default.
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