Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039697942> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2039697942 endingPage "247" @default.
- W2039697942 startingPage "237" @default.
- W2039697942 abstract "To date, no study has described the effects of media flow load on a co-culture model of hepatocytes (HC), hepatic stellate cells (HSC) and endothelial cells (EC). Furthermore, no research has been reported regarding the influence of nitric oxide (NO) concentration in such a co-culture model. Therefore, we developed co-culture models that include two or three of these cell types, and assayed their hepatic functions both in static culture and under flow load. We also measured the NO concentration in each models and inhibited NO production of cells. In static culture, the HC+HSC and HC+HSC+EC models demonstrated higher hepatic function than in the model containing HC alone. Under flow load, all models exhibited higher hepatic function than in static culture. The HC+HSC and HC+HSC+EC models under flow demonstrated the highest hepatic function observed under any condition. In almost all models, NO concentration exhibited the same tendency to increase along with hepatic function, and NO improved hepatic function in vitro without in HC+HSC model under flow load. Inhibition of NO production decreased small levels of hepatic function in HC+HSC and HC+HSC+EC models under flow load. We conclude that co-culture and flow load positively impact hepatic function, and that HSC and NO are related to improvements in hepatic function. Furthermore, we consider that the presence of HSC is responsible for other aspects of improvement in hepatic function." @default.
- W2039697942 created "2016-06-24" @default.
- W2039697942 creator A5003389108 @default.
- W2039697942 creator A5011055049 @default.
- W2039697942 creator A5036778689 @default.
- W2039697942 creator A5090568121 @default.
- W2039697942 date "2012-01-01" @default.
- W2039697942 modified "2023-10-06" @default.
- W2039697942 title "Effect of Flow Load on Hepatic Function in Co-Culture of Hepatocytes with Hepatic Stellate Cells and Endothelial Cells: Relationship between Hepatic Function and Nitric Oxide Concentration <I>in vitro</I>" @default.
- W2039697942 cites W1971200468 @default.
- W2039697942 cites W1973405449 @default.
- W2039697942 cites W1980064380 @default.
- W2039697942 cites W1982174727 @default.
- W2039697942 cites W1983444416 @default.
- W2039697942 cites W1991108927 @default.
- W2039697942 cites W1992973995 @default.
- W2039697942 cites W1993417144 @default.
- W2039697942 cites W2000154294 @default.
- W2039697942 cites W2024440635 @default.
- W2039697942 cites W2024450698 @default.
- W2039697942 cites W2035172806 @default.
- W2039697942 cites W2037323627 @default.
- W2039697942 cites W2038535524 @default.
- W2039697942 cites W2045504931 @default.
- W2039697942 cites W2048159528 @default.
- W2039697942 cites W2048286101 @default.
- W2039697942 cites W2063506293 @default.
- W2039697942 cites W2071313572 @default.
- W2039697942 cites W2078388258 @default.
- W2039697942 cites W2082417305 @default.
- W2039697942 cites W2088190768 @default.
- W2039697942 cites W2091044581 @default.
- W2039697942 cites W2130870274 @default.
- W2039697942 cites W2138825607 @default.
- W2039697942 cites W2147854851 @default.
- W2039697942 cites W2150061383 @default.
- W2039697942 cites W2150884286 @default.
- W2039697942 cites W2152685914 @default.
- W2039697942 doi "https://doi.org/10.1299/jbse.7.237" @default.
- W2039697942 hasPublicationYear "2012" @default.
- W2039697942 type Work @default.
- W2039697942 sameAs 2039697942 @default.
- W2039697942 citedByCount "4" @default.
- W2039697942 countsByYear W20396979422016 @default.
- W2039697942 countsByYear W20396979422017 @default.
- W2039697942 crossrefType "journal-article" @default.
- W2039697942 hasAuthorship W2039697942A5003389108 @default.
- W2039697942 hasAuthorship W2039697942A5011055049 @default.
- W2039697942 hasAuthorship W2039697942A5036778689 @default.
- W2039697942 hasAuthorship W2039697942A5090568121 @default.
- W2039697942 hasBestOaLocation W20396979421 @default.
- W2039697942 hasConcept C126322002 @default.
- W2039697942 hasConcept C134018914 @default.
- W2039697942 hasConcept C14036430 @default.
- W2039697942 hasConcept C176891718 @default.
- W2039697942 hasConcept C185592680 @default.
- W2039697942 hasConcept C202751555 @default.
- W2039697942 hasConcept C2994203108 @default.
- W2039697942 hasConcept C519581460 @default.
- W2039697942 hasConcept C54355233 @default.
- W2039697942 hasConcept C55493867 @default.
- W2039697942 hasConcept C71924100 @default.
- W2039697942 hasConcept C81885089 @default.
- W2039697942 hasConcept C86803240 @default.
- W2039697942 hasConcept C95444343 @default.
- W2039697942 hasConceptScore W2039697942C126322002 @default.
- W2039697942 hasConceptScore W2039697942C134018914 @default.
- W2039697942 hasConceptScore W2039697942C14036430 @default.
- W2039697942 hasConceptScore W2039697942C176891718 @default.
- W2039697942 hasConceptScore W2039697942C185592680 @default.
- W2039697942 hasConceptScore W2039697942C202751555 @default.
- W2039697942 hasConceptScore W2039697942C2994203108 @default.
- W2039697942 hasConceptScore W2039697942C519581460 @default.
- W2039697942 hasConceptScore W2039697942C54355233 @default.
- W2039697942 hasConceptScore W2039697942C55493867 @default.
- W2039697942 hasConceptScore W2039697942C71924100 @default.
- W2039697942 hasConceptScore W2039697942C81885089 @default.
- W2039697942 hasConceptScore W2039697942C86803240 @default.
- W2039697942 hasConceptScore W2039697942C95444343 @default.
- W2039697942 hasIssue "2" @default.
- W2039697942 hasLocation W20396979421 @default.
- W2039697942 hasOpenAccess W2039697942 @default.
- W2039697942 hasPrimaryLocation W20396979421 @default.
- W2039697942 hasRelatedWork W1966504330 @default.
- W2039697942 hasRelatedWork W1974041167 @default.
- W2039697942 hasRelatedWork W1979139803 @default.
- W2039697942 hasRelatedWork W2037631372 @default.
- W2039697942 hasRelatedWork W2037670419 @default.
- W2039697942 hasRelatedWork W2040058909 @default.
- W2039697942 hasRelatedWork W2132898409 @default.
- W2039697942 hasRelatedWork W2748952813 @default.
- W2039697942 hasRelatedWork W3028865823 @default.
- W2039697942 hasRelatedWork W77039285 @default.
- W2039697942 hasVolume "7" @default.
- W2039697942 isParatext "false" @default.
- W2039697942 isRetracted "false" @default.
- W2039697942 magId "2039697942" @default.
- W2039697942 workType "article" @default.