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• W2039698082 endingPage "369" @default.
• W2039698082 startingPage "360" @default.
• W2039698082 abstract "Chromatin remodeling is emerging as a critical regulator of DNA repair factor access to DNA damage, and optimum accessibility of these factors is a major determinant of DNA repair outcome. Hence, chromatin remodeling is likely to play a key role in genome stabilization and tumor suppression. We previously showed that nucleosome eviction near double-strand breaks (DSBs) in yeast is regulated by the INO80 nucleosome remodeling complex and is defective in mutants lacking the Arp8 subunit of INO80. In the absence of homologous donor sequences, RPA recruitment to a DSB appeared normal in arp8Δ, but Rad51 recruitment was defective. We now show that the early strand invasion step of homologous recombination (HR) is markedly delayed in an arp8Δ haploid, but there is only a minor defect in haploid HR efficiency (MAT switching). In an arp8Δ diploid, interhomolog DSB repair by HR shows a modest defect that is partially suppressed by overexpression of Rad51 or its mediator, Rad52. In wild type cells, DSB repair typically results in gene conversion, and most gene conversion tracts are continuous, reflecting efficient mismatch repair of heteroduplex DNA. In contrast, arp8Δ gene conversion tracts are longer and frequently discontinuous, indicating defects in late stages of HR. Interestingly, when a homologous donor sequence is present, Rad51 is recruited normally to a DSB in arp8Δ, but its transfer to the donor is delayed, and this correlates with defective displacement of donor nucleosomes. We propose that retained nucleosomes at donors destabilize heteroduplex DNA or impair mismatch recognition, reflected in delayed strand invasion and altered conversion tracts." @default.
• W2039698082 created "2016-06-24" @default.
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• W2039698082 date "2009-03-01" @default.
• W2039698082 modified "2023-10-14" @default.
• W2039698082 title "INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination" @default.
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• W2039698082 cites W1972689051 @default.
• W2039698082 cites W1974563774 @default.
• W2039698082 cites W1981045115 @default.
• W2039698082 cites W1984919526 @default.
• W2039698082 cites W1989136612 @default.
• W2039698082 cites W1995569417 @default.
• W2039698082 cites W1995586000 @default.
• W2039698082 cites W1995668347 @default.
• W2039698082 cites W2000393605 @default.
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• W2039698082 cites W2009825306 @default.
• W2039698082 cites W2010711320 @default.
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• W2039698082 cites W2022100127 @default.
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• W2039698082 cites W2036546456 @default.
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• W2039698082 cites W2046732438 @default.
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• W2039698082 cites W2065623019 @default.
• W2039698082 cites W2069189464 @default.
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• W2039698082 cites W2075087073 @default.
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• W2039698082 cites W2084664603 @default.
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• W2039698082 cites W2144550200 @default.
• W2039698082 cites W2145340217 @default.
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• W2039698082 cites W2153104389 @default.
• W2039698082 cites W2163370911 @default.
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• W2039698082 doi "https://doi.org/10.1016/j.dnarep.2008.11.014" @default.
• W2039698082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19095087" @default.
• W2039698082 hasPublicationYear "2009" @default.
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