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• W2039698753 abstract "No AccessJournal of UrologyInvestigative Urology1 Oct 1995Effects of Neurokinin Receptor Antagonists on L-DOPA Induced Bladder Hyperactivity in Normal Conscious Rats Osamu Ishizuka, Anders Mattiasson, and Karl-Erik Andersson Osamu IshizukaOsamu Ishizuka More articles by this author , Anders MattiassonAnders Mattiasson More articles by this author , and Karl-Erik AnderssonKarl-Erik Andersson More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66926-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The urodynamic effects of intrathecal neurokinin (NK) receptor blockade on L-dopa-induced bladder hyperactivity were investigated in a rat model. Materials and Methods: Continuous cystometry was performed in normal, conscious, female Sprague-Dawley rats. Results: In rats pretreated with intraperitoneal carbidopa 50 mg./kg., intraperitoneal L-dopa 50 mg./kg. caused bladder hyperactivity that could be attenuated by intrathecal administration of the NK1 receptor selective antagonist SR 140,333 (2 nmol.), whereas the NK2 receptor selective antagonist SR 48,968 (2 nmol.) failed to do so. Combination of SR 140,333 (2 nmol.) and SR 48,968 (2 nmol.), which by itself decreased micturition pressure, practically abolished the L-dopa-induced hyperactivity. Conclusions: The present results suggest that tachykinins, via stimulation of NK1 (and/or NK2) receptors, are involved in L-dopa-induced bladder hyperactivity, most probably at the spinal level. This implies tachykinin involvement in the supraspinal pathways that control the sacral parasympathetic center innervating the urinary bladder. It also implies that spinal NK receptors are a possible target for drugs aimed for elimination of bladder hyperactivity mediated via these pathways. 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Google Scholar 27 : Contraction of urinary bladder by central norepinephrine originating in the locus coeruleus.. J. Urol.1988; 139: 423. Link, Google Scholar Department of Urology and Clinical Pharmacology, Lund University Hospital, Lund, Sweden.© 1995 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byYOSHIMURA N and CHANCELLOR M (2018) Current and Future Pharmacological Treatment for Overactive BladderJournal of Urology, VOL. 168, NO. 5, (1897-1913), Online publication date: 1-Nov-2002.ABDEL-GAWAD M, DION S and ELHILALI M (2018) EVIDENCE OF A PERIPHERAL ROLE OF NEUROKININS IN DETRUSOR HYPERREFLEXIA: A FURTHER STUDY OF SELECTIVE TACHYKININ ANTAGONISTS IN CHRONIC SPINAL INJURED RATSJournal of Urology, VOL. 165, NO. 5, (1739-1744), Online publication date: 1-May-2001. Volume 154Issue 4October 1995Page: 1548-1551 Advertisement Copyright & Permissions© 1995 by American Urological Association, Inc.MetricsAuthor Information Osamu Ishizuka More articles by this author Anders Mattiasson More articles by this author Karl-Erik Andersson More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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