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- W2039710257 abstract "Reelin plays a major role in the development of laminated brain structures. In the developing neocortex and hippocampus, Reelin is secreted by Cajal-Retzius cells in the marginal zone. In the present report, we characterize Reelin-immunoreactive neurons in the perinatal and adult human hippocampal formation. Two main populations of cells are described: Cajal-Retzius cells and interneurons. Cajal-Retzius cells are defined as neurons that coexpress Reelin and p73, a nuclear protein of the p53 family. Colocalization experiments of p73 with calcium-binding proteins indicate that most Cajal-Retzius cells express calretinin, but not calbindin. Cajal-Retzius cell density decreases dramatically during the postnatal period, although a few Reelin/p73-positive neurons are still found in the adult. At birth, Reelin-positive, p73-negative neurons are present in all layers of the hippocampal formation. Their morphology and localization indicate that they belong to a heterogeneous population of interneurons. They are numerous in the strata lacunosum-moleculare and radiatum of CA1-CA3, in the hilus, and in the molecular layer of the dentate gyrus, but less common in stratum oriens and alveus, and rare in the principal cell layers. Subpopulations of Reelin-positive interneurons express calretinin or calbindin. The packing density of Reelin-positive cells decreases postnatally, which may be related to the disappearance of Cajal-Retzius cells and to the growth of the hippocampal formation. The presence of Reelin-immunoreactive cells in the adult hippocampal formation indicates that Reelin is not restricted to development but that it may have additional functions in adult life." @default.
- W2039710257 created "2016-06-24" @default.
- W2039710257 creator A5019937011 @default.
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- W2039710257 date "2003-01-01" @default.
- W2039710257 modified "2023-09-29" @default.
- W2039710257 title "Reelin-expressing neurons in the postnatal and adult human hippocampal formation" @default.
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- W2039710257 doi "https://doi.org/10.1002/hipo.10125" @default.
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