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- W2039713818 abstract "The mammalian target of rapamycin (mTOR) constitutes an integrator of multiple signals and a master pro- grammer of pivotal cellular functions such as cell growth and proliferation. Due to its complex function, it plays a sub- stantial role in homeostasis at molecular, cellular, tissue and organism level and its aberrant activation is implicated in tu- morigenesis and tumor progression. mTOR signaling depends on a number of upstream regulators such as PI3K and Akt, and a number of downstream effectors such as p70 S6 kinase 1 (S6K1) and 4E-BP1. The mTOR pathway seems to be a promising pathway in anticancer treatment and mTOR inhibitors constitute a currently emerging and evaluated class of antitumor agents. Nonetheless, the complexity and multifactorial regulation of this signal transduction pathway make it difficult to determine pivotal parameters such as the optimal therapeutic schedules and the appropriate criteria for the se- lection of patients most likely to respond, which will enable medical oncologists to proceed to the appropriate use of these agents in clinical setting. The complete dissection of both mTOR signaling and the adjacent pathways will enable experts to develop and implement multi-targeted treatment, which appears to be the most promising approach, due to the persis- tent and dynamic interaction between different signaling pathways. Under such circumstances, we will be capable of ex- ploiting mTOR signaling and maximizing the benefit of patients. In the present review, we discuss the regulation of the mTOR signaling, pointing out its implication in the pathogenesis of solid tumors as well as its encouraging therapeutic po- tential." @default.
- W2039713818 created "2016-06-24" @default.
- W2039713818 creator A5003512416 @default.
- W2039713818 creator A5012320509 @default.
- W2039713818 creator A5015800207 @default.
- W2039713818 creator A5038751972 @default.
- W2039713818 date "2009-02-01" @default.
- W2039713818 modified "2023-09-26" @default.
- W2039713818 title "The Biological Role of mTOR in the Pathogenesis of Solid Tumors: An Overview" @default.
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