FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039721676> ?p ?o ?g. }

• W2039721676 endingPage "242" @default.
• W2039721676 startingPage "235" @default.
• W2039721676 abstract "Summary The purpose of this study was to examine whether several allelic variants in the polymorphic interleukin (IL)‐10 promoter region were related with an increased risk of developing systemic lupus erythematosus (SLE) in Spanish patients from Canary Islands. Microsatellites (MS) at positions –4000 and –1200 (IL10R and IL10G, respectively) and single nucleotide polymorphisms (SNPs) (MS) at positions –1082G/A, –819C/T and –592C/A of the IL‐10 promoter were analysed in patients with SLE and healthy controls from Canary Islands (Spain). We found that SNPs but not MS were associated with SLE. The GCC haplotype frequency was significantly higher in SLE patients (0.43) than in healthy donors (0.33) [ P = 0.02; OR = 1.50 (95% CI = 1.06–2.14)], whereas the ACC haplotype was less represented in patients (0.28 vs. 0.37) [ P = 0.02; OR = 0.64 (95% CI = 0.44–0.92)]. To assess the functional role of genotypes, serum IL‐10 levels from patients and controls were quantified by ELISA. Also, the lipopolysaccharide‐induced IL‐10 secretion by monocytes from healthy controls was evaluated in vitro . Serum IL‐10 levels were higher in patients [median (interquartile range) = 2.8 pg/mL (1.8–4.2)] than in controls [0.9 pg/mL (0–3.5)] ( P = 0.02), but no association was observed between serum IL‐10 levels or lipopolysaccharide‐induced IL‐10 secretion and the IL‐10 promoter haplotypes. These data suggest that the IL‐10 promoter haplotype that produces higher levels of cytokine is associated with SLE in patients from Canary Islands." @default.
• W2039721676 created "2016-06-24" @default.
• W2039721676 creator A5012822500 @default.
• W2039721676 creator A5013324467 @default.
• W2039721676 creator A5017307142 @default.
• W2039721676 creator A5022075663 @default.
• W2039721676 creator A5025267881 @default.
• W2039721676 creator A5031297709 @default.
• W2039721676 creator A5035683885 @default.
• W2039721676 creator A5036195339 @default.
• W2039721676 creator A5062257154 @default.
• W2039721676 creator A5069137807 @default.
• W2039721676 creator A5078953154 @default.
• W2039721676 creator A5086191681 @default.
• W2039721676 date "2008-04-08" @default.
• W2039721676 modified "2023-10-16" @default.
• W2039721676 title "Interleukin-10 promoter polymorphisms in patients with systemic lupus erythematosus from the Canary Islands" @default.
• W2039721676 cites W1528386279 @default.
• W2039721676 cites W1966755507 @default.
• W2039721676 cites W1968009444 @default.
• W2039721676 cites W1975534320 @default.
• W2039721676 cites W1976471041 @default.
• W2039721676 cites W1981255896 @default.
• W2039721676 cites W1985409443 @default.
• W2039721676 cites W2006619058 @default.
• W2039721676 cites W2007454356 @default.
• W2039721676 cites W2016057757 @default.
• W2039721676 cites W2016283253 @default.
• W2039721676 cites W2016318369 @default.
• W2039721676 cites W2016937109 @default.
• W2039721676 cites W2016954412 @default.
• W2039721676 cites W2017912256 @default.
• W2039721676 cites W2026425087 @default.
• W2039721676 cites W2033998941 @default.
• W2039721676 cites W2045910289 @default.
• W2039721676 cites W2086751610 @default.
• W2039721676 cites W2089907042 @default.
• W2039721676 cites W2100186575 @default.
• W2039721676 cites W2101771134 @default.
• W2039721676 cites W2105925268 @default.
• W2039721676 cites W2117229410 @default.
• W2039721676 cites W2117556617 @default.
• W2039721676 cites W2122385641 @default.
• W2039721676 cites W2133422071 @default.
• W2039721676 cites W2142014631 @default.
• W2039721676 cites W2146203649 @default.
• W2039721676 cites W2148126661 @default.
• W2039721676 cites W2156103383 @default.
• W2039721676 cites W2161074777 @default.
• W2039721676 cites W2337416112 @default.
• W2039721676 doi "https://doi.org/10.1111/j.1744-313x.2008.00762.x" @default.
• W2039721676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18397303" @default.
• W2039721676 hasPublicationYear "2008" @default.
• W2039721676 type Work @default.
• W2039721676 sameAs 2039721676 @default.
• W2039721676 citedByCount "28" @default.
• W2039721676 countsByYear W20397216762012 @default.
• W2039721676 countsByYear W20397216762013 @default.
• W2039721676 countsByYear W20397216762014 @default.
• W2039721676 countsByYear W20397216762015 @default.
• W2039721676 countsByYear W20397216762016 @default.
• W2039721676 countsByYear W20397216762018 @default.
• W2039721676 countsByYear W20397216762019 @default.
• W2039721676 countsByYear W20397216762020 @default.
• W2039721676 countsByYear W20397216762021 @default.
• W2039721676 crossrefType "journal-article" @default.
• W2039721676 hasAuthorship W2039721676A5012822500 @default.
• W2039721676 hasAuthorship W2039721676A5013324467 @default.
• W2039721676 hasAuthorship W2039721676A5017307142 @default.
• W2039721676 hasAuthorship W2039721676A5022075663 @default.
• W2039721676 hasAuthorship W2039721676A5025267881 @default.
• W2039721676 hasAuthorship W2039721676A5031297709 @default.
• W2039721676 hasAuthorship W2039721676A5035683885 @default.
• W2039721676 hasAuthorship W2039721676A5036195339 @default.
• W2039721676 hasAuthorship W2039721676A5062257154 @default.
• W2039721676 hasAuthorship W2039721676A5069137807 @default.
• W2039721676 hasAuthorship W2039721676A5078953154 @default.
• W2039721676 hasAuthorship W2039721676A5086191681 @default.
• W2039721676 hasConcept C101762097 @default.
• W2039721676 hasConcept C104317684 @default.
• W2039721676 hasConcept C119060515 @default.
• W2039721676 hasConcept C126322002 @default.
• W2039721676 hasConcept C135763542 @default.
• W2039721676 hasConcept C150194340 @default.
• W2039721676 hasConcept C153209595 @default.
• W2039721676 hasConcept C180754005 @default.
• W2039721676 hasConcept C187316574 @default.
• W2039721676 hasConcept C197754878 @default.
• W2039721676 hasConcept C203014093 @default.
• W2039721676 hasConcept C2778690821 @default.
• W2039721676 hasConcept C54355233 @default.
• W2039721676 hasConcept C71924100 @default.
• W2039721676 hasConcept C74172505 @default.
• W2039721676 hasConcept C86803240 @default.
• W2039721676 hasConceptScore W2039721676C101762097 @default.
• W2039721676 hasConceptScore W2039721676C104317684 @default.
• W2039721676 hasConceptScore W2039721676C119060515 @default.
• W2039721676 hasConceptScore W2039721676C126322002 @default.

• next