FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039727979> ?p ?o ?g. }

• W2039727979 endingPage "3990" @default.
• W2039727979 startingPage "3979" @default.
• W2039727979 abstract "Fragile X syndrome (FXS) is the most frequent cause of inherited mental retardation and is largely caused by a loss of expression of fragile X mental retardation protein (FMRP), encoded by fragile X retardation gene-1 (Fmr1). FMRP is a multifunction protein, with intrinsic RNA-binding properties, which is a component of ribonucleoprotein complex associated with polyribosomes. The properties of FMRP indicate that it might participate in post-transcriptional processes in the regulation of some mRNA species, including localization, stability and translational control. However, the function of FMRP related to the pathologenesis in FXS is largely unknown. Many efforts were undertaken to identify the putative specific RNA targets as well as the FMRP-related proteins and to identify the effect of FMRP absence on the corresponding proteins. Here we present our efforts using proteomics approach to explore the differential expression profiling of mouse cerebella immortal cell, in which we changed the expression of FMRP by expressing Fmr1 gene with nuclear export signal (NES) mutation. This mutation makes FMRP unable to shuttle from nucleus to cytoplasm and leads to nuclear instead of cytoplasmic location as usual, which was hypothesized to affect the pathways of groups of RNAs or proteins related with FMRP. In present study, 56 proteins were found to be differentially expressed in transfected R2 neuronal cells, including 16 decreased expressions and 40 increased expressions. The differentially expressed proteins play roles in diverse physiological processes, such as neuronal plasticity, spermatogenesis and craniofacial and limb development etc. In addition, the expressions of three mRNA identified as FMRP targets in fragile X cell were tested in present model cells. All these results provide new insights to the role of FMRP in the disease." @default.
• W2039727979 created "2016-06-24" @default.
• W2039727979 creator A5007314199 @default.
• W2039727979 creator A5007699783 @default.
• W2039727979 creator A5068093752 @default.
• W2039727979 creator A5084565202 @default.
• W2039727979 date "2005-10-01" @default.
• W2039727979 modified "2023-10-16" @default.
• W2039727979 title "Expression of fragile X mental retardation-1 gene with nuclear export signal mutation changes the expression profiling of mouse cerebella immortal neuronal cell" @default.
• W2039727979 cites W1522779995 @default.
• W2039727979 cites W1955701572 @default.
• W2039727979 cites W1971436788 @default.
• W2039727979 cites W1977257584 @default.
• W2039727979 cites W1979293200 @default.
• W2039727979 cites W1986804263 @default.
• W2039727979 cites W1990073151 @default.
• W2039727979 cites W1991587102 @default.
• W2039727979 cites W1997829417 @default.
• W2039727979 cites W2002364516 @default.
• W2039727979 cites W2008689421 @default.
• W2039727979 cites W2014055734 @default.
• W2039727979 cites W2014806877 @default.
• W2039727979 cites W2035391407 @default.
• W2039727979 cites W2036338927 @default.
• W2039727979 cites W2039189257 @default.
• W2039727979 cites W2043752092 @default.
• W2039727979 cites W2048108096 @default.
• W2039727979 cites W2051681013 @default.
• W2039727979 cites W2055612111 @default.
• W2039727979 cites W2057234832 @default.
• W2039727979 cites W2060969464 @default.
• W2039727979 cites W2061795784 @default.
• W2039727979 cites W2069338832 @default.
• W2039727979 cites W2073832046 @default.
• W2039727979 cites W2074124598 @default.
• W2039727979 cites W2080125447 @default.
• W2039727979 cites W2080489609 @default.
• W2039727979 cites W2082786577 @default.
• W2039727979 cites W2090193932 @default.
• W2039727979 cites W2090425574 @default.
• W2039727979 cites W2092261455 @default.
• W2039727979 cites W2093828656 @default.
• W2039727979 cites W2096252283 @default.
• W2039727979 cites W2098756736 @default.
• W2039727979 cites W2106239245 @default.
• W2039727979 cites W2110395594 @default.
• W2039727979 cites W2110811750 @default.
• W2039727979 cites W2114955795 @default.
• W2039727979 cites W2116190619 @default.
• W2039727979 cites W2118593615 @default.
• W2039727979 cites W2120211068 @default.
• W2039727979 cites W2120805065 @default.
• W2039727979 cites W2125366349 @default.
• W2039727979 cites W2127328679 @default.
• W2039727979 cites W2132943956 @default.
• W2039727979 cites W2137220579 @default.
• W2039727979 cites W2138855766 @default.
• W2039727979 cites W2151122946 @default.
• W2039727979 cites W2152268460 @default.
• W2039727979 cites W2158367400 @default.
• W2039727979 cites W2164962682 @default.
• W2039727979 cites W2171811534 @default.
• W2039727979 cites W2217415287 @default.
• W2039727979 doi "https://doi.org/10.1002/pmic.200401252" @default.
• W2039727979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16130171" @default.
• W2039727979 hasPublicationYear "2005" @default.
• W2039727979 type Work @default.
• W2039727979 sameAs 2039727979 @default.
• W2039727979 citedByCount "6" @default.
• W2039727979 countsByYear W20397279792013 @default.
• W2039727979 countsByYear W20397279792015 @default.
• W2039727979 countsByYear W20397279792016 @default.
• W2039727979 countsByYear W20397279792021 @default.
• W2039727979 crossrefType "journal-article" @default.
• W2039727979 hasAuthorship W2039727979A5007314199 @default.
• W2039727979 hasAuthorship W2039727979A5007699783 @default.
• W2039727979 hasAuthorship W2039727979A5068093752 @default.
• W2039727979 hasAuthorship W2039727979A5084565202 @default.
• W2039727979 hasBestOaLocation W20397279791 @default.
• W2039727979 hasConcept C104317684 @default.
• W2039727979 hasConcept C105580179 @default.
• W2039727979 hasConcept C149364088 @default.
• W2039727979 hasConcept C150194340 @default.
• W2039727979 hasConcept C190062978 @default.
• W2039727979 hasConcept C2777630245 @default.
• W2039727979 hasConcept C2779063550 @default.
• W2039727979 hasConcept C3020422209 @default.
• W2039727979 hasConcept C39685955 @default.
• W2039727979 hasConcept C41282012 @default.
• W2039727979 hasConcept C46111723 @default.
• W2039727979 hasConcept C54355233 @default.
• W2039727979 hasConcept C54757728 @default.
• W2039727979 hasConcept C65666806 @default.
• W2039727979 hasConcept C67705224 @default.
• W2039727979 hasConcept C75934600 @default.
• W2039727979 hasConcept C86803240 @default.
• W2039727979 hasConcept C88478588 @default.
• W2039727979 hasConcept C95444343 @default.

• next