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- W2039732801 abstract "vlf-1is a baculovirus gene that regulates very late gene expression (J. R. McLachlin and L. K. Miller,J. Virol.,68, 7746–7756, 1994) and also plays a crucial role in the replication of the budded form ofAutographa californicanuclear polyhedrosis virus (AcMNPV) (S. Yang and L. K. Miller, “Expression and mutational analysis of the baculovirus very late factor 1 (vlf-1) gene.”Virology,245, 99–109, 1998). To examine the influence ofvlf-1expression on baculovirus infection, we constructed recombinant viruses that expressed only low levels of VLF-1 and recombinants withvlf-1under the control of different promoters. Viruses with mutant alleles ofvlf-1that produced low levels of VLF-1 replicated the budded form of the virus normally but produced no occlusion bodies. Thus, a higher concentration of VLF-1 was needed to activate very late gene expression than was needed to support budded virus production. By altering the level and/or timing ofvlf-1expression, the timing of polyhedrin gene (polh) expression, which normally occurs very late in infection, could be advanced or delayed. Early overexpression ofvlf-1increased the level of expression from thepolhpromoter but caused premature cellular disintegration. The data indicate that VLF-1 is the limiting factor in very late gene expression and that the level of VLF-1 controls the onset of occlusion." @default.
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- W2039732801 date "1998-08-01" @default.
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- W2039732801 title "Control of Baculovirus Polyhedrin Gene Expression by Very Late Factor 1" @default.
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- W2039732801 doi "https://doi.org/10.1006/viro.1998.9272" @default.
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