Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039734419> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2039734419 endingPage "725" @default.
- W2039734419 startingPage "719" @default.
- W2039734419 abstract "The reduction in apoptosis caused by short-term exposure of CEM x174 cells infected with SIVmac239 to morphine was investigated. Eeffects of morphine on the viability of normal and infected CEM x174 cells were determined by MTS assay. Apoptosis induced by SIVmac239 and the effects of morphine were analyzed by flow cytometry. cAMP levels, PKA activity, and the resulting histone H3 phosphorylation levels were measured. The results show a pronounced decrease in numbers of infected SIVmac239 cells compared to controls. Morphine elevated cell viability in the infected groups. Annexin V binding assays showed that 1 μmol l−1morphine increased the percentage of viable cells and decreased apoptotic cells. Morphine also downregulated cAMP and PKA activity in both groups, but more markedly in the infected group. Histone H3 phosphorylation was elevated after virus infection and decreased in the presence of morphine. The results indicate that the cAMP-PKA signal transduction cascade is involved in morphine regulation of early SIVmac239-induced apoptosis." @default.
- W2039734419 created "2016-06-24" @default.
- W2039734419 creator A5007909190 @default.
- W2039734419 creator A5022895118 @default.
- W2039734419 creator A5039153671 @default.
- W2039734419 creator A5042215196 @default.
- W2039734419 creator A5067582437 @default.
- W2039734419 creator A5081761398 @default.
- W2039734419 date "2003-01-01" @default.
- W2039734419 modified "2023-10-04" @default.
- W2039734419 title "Morphine alleviates early stages of apoptosis in cultured CEM x174 cells infected with simian immunodeficiency virus" @default.
- W2039734419 cites W1484896659 @default.
- W2039734419 cites W1600881103 @default.
- W2039734419 cites W1913909659 @default.
- W2039734419 cites W1965786497 @default.
- W2039734419 cites W1975319708 @default.
- W2039734419 cites W2003060818 @default.
- W2039734419 cites W2012409389 @default.
- W2039734419 cites W2015285602 @default.
- W2039734419 cites W2018976363 @default.
- W2039734419 cites W2038320218 @default.
- W2039734419 cites W203871967 @default.
- W2039734419 cites W2062205849 @default.
- W2039734419 cites W2063649408 @default.
- W2039734419 cites W2073028084 @default.
- W2039734419 cites W2078133688 @default.
- W2039734419 cites W2079726240 @default.
- W2039734419 cites W2132755552 @default.
- W2039734419 cites W2137298832 @default.
- W2039734419 cites W2323124509 @default.
- W2039734419 cites W2348790565 @default.
- W2039734419 cites W2366376653 @default.
- W2039734419 doi "https://doi.org/10.1016/s1065-6995(03)00141-0" @default.
- W2039734419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12972276" @default.
- W2039734419 hasPublicationYear "2003" @default.
- W2039734419 type Work @default.
- W2039734419 sameAs 2039734419 @default.
- W2039734419 citedByCount "13" @default.
- W2039734419 countsByYear W20397344192012 @default.
- W2039734419 countsByYear W20397344192015 @default.
- W2039734419 crossrefType "journal-article" @default.
- W2039734419 hasAuthorship W2039734419A5007909190 @default.
- W2039734419 hasAuthorship W2039734419A5022895118 @default.
- W2039734419 hasAuthorship W2039734419A5039153671 @default.
- W2039734419 hasAuthorship W2039734419A5042215196 @default.
- W2039734419 hasAuthorship W2039734419A5067582437 @default.
- W2039734419 hasAuthorship W2039734419A5081761398 @default.
- W2039734419 hasConcept C11960822 @default.
- W2039734419 hasConcept C153911025 @default.
- W2039734419 hasConcept C185592680 @default.
- W2039734419 hasConcept C190283241 @default.
- W2039734419 hasConcept C203014093 @default.
- W2039734419 hasConcept C2522874641 @default.
- W2039734419 hasConcept C2777389121 @default.
- W2039734419 hasConcept C2777995582 @default.
- W2039734419 hasConcept C53227056 @default.
- W2039734419 hasConcept C553184892 @default.
- W2039734419 hasConcept C55493867 @default.
- W2039734419 hasConcept C86803240 @default.
- W2039734419 hasConcept C88634738 @default.
- W2039734419 hasConcept C95444343 @default.
- W2039734419 hasConcept C98274493 @default.
- W2039734419 hasConceptScore W2039734419C11960822 @default.
- W2039734419 hasConceptScore W2039734419C153911025 @default.
- W2039734419 hasConceptScore W2039734419C185592680 @default.
- W2039734419 hasConceptScore W2039734419C190283241 @default.
- W2039734419 hasConceptScore W2039734419C203014093 @default.
- W2039734419 hasConceptScore W2039734419C2522874641 @default.
- W2039734419 hasConceptScore W2039734419C2777389121 @default.
- W2039734419 hasConceptScore W2039734419C2777995582 @default.
- W2039734419 hasConceptScore W2039734419C53227056 @default.
- W2039734419 hasConceptScore W2039734419C553184892 @default.
- W2039734419 hasConceptScore W2039734419C55493867 @default.
- W2039734419 hasConceptScore W2039734419C86803240 @default.
- W2039734419 hasConceptScore W2039734419C88634738 @default.
- W2039734419 hasConceptScore W2039734419C95444343 @default.
- W2039734419 hasConceptScore W2039734419C98274493 @default.
- W2039734419 hasIssue "9" @default.
- W2039734419 hasLocation W20397344191 @default.
- W2039734419 hasLocation W20397344192 @default.
- W2039734419 hasOpenAccess W2039734419 @default.
- W2039734419 hasPrimaryLocation W20397344191 @default.
- W2039734419 hasRelatedWork W1505894769 @default.
- W2039734419 hasRelatedWork W2090644874 @default.
- W2039734419 hasRelatedWork W2349578600 @default.
- W2039734419 hasRelatedWork W2353925213 @default.
- W2039734419 hasRelatedWork W2365320098 @default.
- W2039734419 hasRelatedWork W2367894058 @default.
- W2039734419 hasRelatedWork W2372398023 @default.
- W2039734419 hasRelatedWork W2380795534 @default.
- W2039734419 hasRelatedWork W2381275445 @default.
- W2039734419 hasRelatedWork W2391870033 @default.
- W2039734419 hasVolume "27" @default.
- W2039734419 isParatext "false" @default.
- W2039734419 isRetracted "false" @default.
- W2039734419 magId "2039734419" @default.
- W2039734419 workType "article" @default.