Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039736060> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2039736060 endingPage "1462" @default.
- W2039736060 startingPage "1457" @default.
- W2039736060 abstract "To examine the efficacy and toxicity of oral 3,4 diaminopyridine (DAP) in dosages up to 100 mg/day, 36 patients with multiple sclerosis (MS) enrolled in a randomized, double-blind, placebo-controlled, crossover trial. The primary outcome measure was improvement of a prospectively defined neurologic deficit, which was leg weakness in 34 patients. Secondary outcome measures included the patient's subjective response, scored manual motor testing (MMT) of leg strength, scored leg strength from videotaped motor testing (VMT), quadriceps and hamstrings strength (QMT) measured by isometric dynamometry, neuropsychological testing (NPT), ambulation index (AI), and Expanded Disability Status Scale (EDSS) score. Paresthesias and abdominal pain were common and were dose limiting in eight patients. Three patients had episodes of confusion, and one patient had a seizure while on DAP. Eight patients withdrew from the study, leaving 28 evaluable patients for the efficacy analysis. The prospectively defined neurologic deficit improved in 24 patients-22 on DAP and 2 on placebo (p = 0.0005). All improvements were in leg weakness. Subjective response and measures of leg strength and function (MMT, VMT, QMT, and AI) improved on DAP compared with placebo. Neither NPT nor EDSS scores improved. DAP treatment can induce improvements in leg strength in MS patients, but toxicity is limiting in many patients." @default.
- W2039736060 created "2016-06-24" @default.
- W2039736060 creator A5011962548 @default.
- W2039736060 creator A5014108025 @default.
- W2039736060 creator A5021299578 @default.
- W2039736060 creator A5041320752 @default.
- W2039736060 creator A5056460527 @default.
- W2039736060 creator A5061646633 @default.
- W2039736060 creator A5064112468 @default.
- W2039736060 creator A5076747036 @default.
- W2039736060 creator A5081342306 @default.
- W2039736060 creator A5087339613 @default.
- W2039736060 creator A5089130624 @default.
- W2039736060 date "1996-12-01" @default.
- W2039736060 modified "2023-09-25" @default.
- W2039736060 title "Treatment with oral 3,4 diaminopyridine improves leg strength in multiple sclerosis patients: Results of a randomized, double-blind, placebo-controlled, crossover trial" @default.
- W2039736060 cites W1985939052 @default.
- W2039736060 cites W1986471654 @default.
- W2039736060 cites W1992220804 @default.
- W2039736060 cites W2031982863 @default.
- W2039736060 cites W2047157165 @default.
- W2039736060 cites W2085668981 @default.
- W2039736060 cites W2283494273 @default.
- W2039736060 cites W2318143408 @default.
- W2039736060 cites W2324797293 @default.
- W2039736060 cites W2330005137 @default.
- W2039736060 cites W2414262416 @default.
- W2039736060 doi "https://doi.org/10.1212/wnl.47.6.1457" @default.
- W2039736060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8960727" @default.
- W2039736060 hasPublicationYear "1996" @default.
- W2039736060 type Work @default.
- W2039736060 sameAs 2039736060 @default.
- W2039736060 citedByCount "70" @default.
- W2039736060 countsByYear W20397360602012 @default.
- W2039736060 countsByYear W20397360602013 @default.
- W2039736060 countsByYear W20397360602014 @default.
- W2039736060 countsByYear W20397360602016 @default.
- W2039736060 countsByYear W20397360602018 @default.
- W2039736060 countsByYear W20397360602021 @default.
- W2039736060 crossrefType "journal-article" @default.
- W2039736060 hasAuthorship W2039736060A5011962548 @default.
- W2039736060 hasAuthorship W2039736060A5014108025 @default.
- W2039736060 hasAuthorship W2039736060A5021299578 @default.
- W2039736060 hasAuthorship W2039736060A5041320752 @default.
- W2039736060 hasAuthorship W2039736060A5056460527 @default.
- W2039736060 hasAuthorship W2039736060A5061646633 @default.
- W2039736060 hasAuthorship W2039736060A5064112468 @default.
- W2039736060 hasAuthorship W2039736060A5076747036 @default.
- W2039736060 hasAuthorship W2039736060A5081342306 @default.
- W2039736060 hasAuthorship W2039736060A5087339613 @default.
- W2039736060 hasAuthorship W2039736060A5089130624 @default.
- W2039736060 hasConcept C141071460 @default.
- W2039736060 hasConcept C142724271 @default.
- W2039736060 hasConcept C168563851 @default.
- W2039736060 hasConcept C1862650 @default.
- W2039736060 hasConcept C204787440 @default.
- W2039736060 hasConcept C27081682 @default.
- W2039736060 hasConcept C2780247198 @default.
- W2039736060 hasConcept C42219234 @default.
- W2039736060 hasConcept C71924100 @default.
- W2039736060 hasConcept C87813604 @default.
- W2039736060 hasConcept C99508421 @default.
- W2039736060 hasConceptScore W2039736060C141071460 @default.
- W2039736060 hasConceptScore W2039736060C142724271 @default.
- W2039736060 hasConceptScore W2039736060C168563851 @default.
- W2039736060 hasConceptScore W2039736060C1862650 @default.
- W2039736060 hasConceptScore W2039736060C204787440 @default.
- W2039736060 hasConceptScore W2039736060C27081682 @default.
- W2039736060 hasConceptScore W2039736060C2780247198 @default.
- W2039736060 hasConceptScore W2039736060C42219234 @default.
- W2039736060 hasConceptScore W2039736060C71924100 @default.
- W2039736060 hasConceptScore W2039736060C87813604 @default.
- W2039736060 hasConceptScore W2039736060C99508421 @default.
- W2039736060 hasIssue "6" @default.
- W2039736060 hasLocation W20397360601 @default.
- W2039736060 hasLocation W20397360602 @default.
- W2039736060 hasOpenAccess W2039736060 @default.
- W2039736060 hasPrimaryLocation W20397360601 @default.
- W2039736060 hasRelatedWork W1586374228 @default.
- W2039736060 hasRelatedWork W2003938723 @default.
- W2039736060 hasRelatedWork W2047967234 @default.
- W2039736060 hasRelatedWork W2089201504 @default.
- W2039736060 hasRelatedWork W2118496982 @default.
- W2039736060 hasRelatedWork W2364998975 @default.
- W2039736060 hasRelatedWork W2369162477 @default.
- W2039736060 hasRelatedWork W2439875401 @default.
- W2039736060 hasRelatedWork W4238867864 @default.
- W2039736060 hasRelatedWork W2525756941 @default.
- W2039736060 hasVolume "47" @default.
- W2039736060 isParatext "false" @default.
- W2039736060 isRetracted "false" @default.
- W2039736060 magId "2039736060" @default.
- W2039736060 workType "article" @default.