Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039736384> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2039736384 endingPage "140" @default.
- W2039736384 startingPage "136" @default.
- W2039736384 abstract "We investigated the changes in nitric oxide (NO) concentration in the brain of the rabbit by measuring NO-related electrical current. Seventeen Japanese white rabbits were anesthetized with pentobarbital sodium and mechanically ventilated with tracheotomy tubes. An NO-selective electrode was used for the detection of NO. After a round craniotomy in the left parietal lobe, an NO-sensitive electrode was placed in the brain. Rabbits were hemorrhaged to a mean arterial blood pressure of 35 ± 7 mmHg, from a baseline of 112 ± 12 mmHg (mean ± SD). The shock was maintained for 5 min. The mean extracted blood volume was 77 ± 17 mL. Then, retransfusion of shed blood caused a rapid restoration of mean arterial blood pressure. The amount of time required to induce hemorrhagic shock was 261 ± 34 s. The time required to retransfuse the extracted blood was 233 ± 43 s (p > .05). During shock, the NO-selective electrode produced an extensive increase in current, from 110 ± 94.5 pA to 1010 ± 543 pA (mean ± SD, p < .001). The current continued to increase for a few minutes after the recovery from shock, with a maximal increase reaching 1245 ± 515 pA (p < .001). This enhanced release of NO-related current (1,132%) recovered to the baseline level at 44 ± 7 min after retransfusion. When the same investigation was performed on the same animals on which had been placed the same electrode pretreated with NG-nitro-L-arginine methylester (L-NAME) 30 mg/kg intravenously, NO-related current increased from 101 ± 158 to a maximum of 860 ± 406 pA (752%). Our results suggest that NO may play an important role in the brain during the early period of hemorrhagic shock, and that L-NAME 30 mg/kg intravenously might not inhibit the NO production in the parietal lobe, probably due to a blood-brain barrier to the nitric oxide synthase-inhibiting drug." @default.
- W2039736384 created "2016-06-24" @default.
- W2039736384 creator A5017979502 @default.
- W2039736384 creator A5036907221 @default.
- W2039736384 creator A5066786711 @default.
- W2039736384 creator A5086200475 @default.
- W2039736384 date "1997-08-01" @default.
- W2039736384 modified "2023-09-27" @default.
- W2039736384 title "NITRIC OXIDE IN THE BRAIN INCREASES DURING A SHORT PERIOD OF HEMORRHAGIC SHOCK IN THE RABBIT" @default.
- W2039736384 doi "https://doi.org/10.1097/00024382-199708000-00013" @default.
- W2039736384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9261905" @default.
- W2039736384 hasPublicationYear "1997" @default.
- W2039736384 type Work @default.
- W2039736384 sameAs 2039736384 @default.
- W2039736384 citedByCount "9" @default.
- W2039736384 crossrefType "journal-article" @default.
- W2039736384 hasAuthorship W2039736384A5017979502 @default.
- W2039736384 hasAuthorship W2039736384A5036907221 @default.
- W2039736384 hasAuthorship W2039736384A5066786711 @default.
- W2039736384 hasAuthorship W2039736384A5086200475 @default.
- W2039736384 hasBestOaLocation W20397363841 @default.
- W2039736384 hasConcept C126322002 @default.
- W2039736384 hasConcept C2776452961 @default.
- W2039736384 hasConcept C2776755955 @default.
- W2039736384 hasConcept C2777953023 @default.
- W2039736384 hasConcept C2781300812 @default.
- W2039736384 hasConcept C37557685 @default.
- W2039736384 hasConcept C42219234 @default.
- W2039736384 hasConcept C519581460 @default.
- W2039736384 hasConcept C71924100 @default.
- W2039736384 hasConcept C84393581 @default.
- W2039736384 hasConceptScore W2039736384C126322002 @default.
- W2039736384 hasConceptScore W2039736384C2776452961 @default.
- W2039736384 hasConceptScore W2039736384C2776755955 @default.
- W2039736384 hasConceptScore W2039736384C2777953023 @default.
- W2039736384 hasConceptScore W2039736384C2781300812 @default.
- W2039736384 hasConceptScore W2039736384C37557685 @default.
- W2039736384 hasConceptScore W2039736384C42219234 @default.
- W2039736384 hasConceptScore W2039736384C519581460 @default.
- W2039736384 hasConceptScore W2039736384C71924100 @default.
- W2039736384 hasConceptScore W2039736384C84393581 @default.
- W2039736384 hasIssue "2" @default.
- W2039736384 hasLocation W20397363841 @default.
- W2039736384 hasLocation W20397363842 @default.
- W2039736384 hasOpenAccess W2039736384 @default.
- W2039736384 hasPrimaryLocation W20397363841 @default.
- W2039736384 hasRelatedWork W139119628 @default.
- W2039736384 hasRelatedWork W2041638296 @default.
- W2039736384 hasRelatedWork W2120647838 @default.
- W2039736384 hasRelatedWork W2144678055 @default.
- W2039736384 hasRelatedWork W2195513968 @default.
- W2039736384 hasRelatedWork W2272576922 @default.
- W2039736384 hasRelatedWork W2285354716 @default.
- W2039736384 hasRelatedWork W2352144678 @default.
- W2039736384 hasRelatedWork W2364045690 @default.
- W2039736384 hasRelatedWork W2431269862 @default.
- W2039736384 hasVolume "8" @default.
- W2039736384 isParatext "false" @default.
- W2039736384 isRetracted "false" @default.
- W2039736384 magId "2039736384" @default.
- W2039736384 workType "article" @default.