FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039740044> ?p ?o ?g. }

• W2039740044 abstract "Ca(2+)/calmodulin-dependent protein kinase II is a synapse-enriched kinase in mammalian brains. This kinase interacts with various synaptic proteins to regulate expression and function of interacting proteins and thereby modulates synaptic transmission. CaMKII and its interacting partners are also believed to play a pivotal role in the pathogenesis of various neurological and neurodegenerative disorders, such as Parkinson's disease (PD). In this study, we found that CaMKIIα binds to dopamine D2 receptors (D2R) in vitro. A distal region in the D2R third intracellular loop harbors CaMKIIα binding. Endogenous CaMKIIα was also found to interact with native D2Rs in rat striatal neurons in which D2Rs are expressed at a high level. In addition, in a rat 6-hydroxydopamine lesioned model of PD, chronic levodopa administration induced characteristic dyskinesia. In parallel, levodopa induced an increase in CaMKIIα-D2R interactions in striatal neurons. Intrastriatal injection of a Tat-fusion and CaMKIIα-D2R interaction-dead peptide (Tat-D2Ri) reversed this increase in the interaction between two proteins. Tat-D2Ri also alleviated dyskinetic behaviors induced by levodopa. These results reveal a new interaction between CaMKIIα and D2Rs in striatal neurons which is sensitive to long-term administration of levodopa in PD rats. Prevention of the response of CaMKIIα-D2R interactions to levodopa can alleviate levodopa-induced dyskinesia." @default.
• W2039740044 created "2016-06-24" @default.
• W2039740044 creator A5055914209 @default.
• W2039740044 creator A5069120338 @default.
• W2039740044 creator A5081428042 @default.
• W2039740044 creator A5084472288 @default.
• W2039740044 date "2014-10-29" @default.
• W2039740044 modified "2023-09-27" @default.
• W2039740044 title "Interactions of CaMKII with dopamine D2 receptors: roles in levodopa-induced dyskinesia in 6-hydroxydopamine lesioned Parkinson's rats" @default.
• W2039740044 cites W100092412 @default.
• W2039740044 cites W1592187810 @default.
• W2039740044 cites W1612942453 @default.
• W2039740044 cites W1966260988 @default.
• W2039740044 cites W1975027397 @default.
• W2039740044 cites W1977533543 @default.
• W2039740044 cites W1990677732 @default.
• W2039740044 cites W2003856021 @default.
• W2039740044 cites W2013295462 @default.
• W2039740044 cites W2013367772 @default.
• W2039740044 cites W2023894581 @default.
• W2039740044 cites W2025080281 @default.
• W2039740044 cites W2033294541 @default.
• W2039740044 cites W2034592530 @default.
• W2039740044 cites W2035286056 @default.
• W2039740044 cites W2035880579 @default.
• W2039740044 cites W2036341774 @default.
• W2039740044 cites W2052953036 @default.
• W2039740044 cites W2062785655 @default.
• W2039740044 cites W2067883893 @default.
• W2039740044 cites W2069618648 @default.
• W2039740044 cites W2081445047 @default.
• W2039740044 cites W2082842394 @default.
• W2039740044 cites W2087320910 @default.
• W2039740044 cites W2105668301 @default.
• W2039740044 cites W2106389606 @default.
• W2039740044 cites W2116560077 @default.
• W2039740044 cites W2141971264 @default.
• W2039740044 cites W2143794501 @default.
• W2039740044 cites W2149309211 @default.
• W2039740044 cites W2154011816 @default.
• W2039740044 cites W2159891593 @default.
• W2039740044 cites W4239908405 @default.
• W2039740044 doi "https://doi.org/10.1038/srep06811" @default.
• W2039740044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4212240" @default.
• W2039740044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25351365" @default.
• W2039740044 hasPublicationYear "2014" @default.
• W2039740044 type Work @default.
• W2039740044 sameAs 2039740044 @default.
• W2039740044 citedByCount "38" @default.
• W2039740044 countsByYear W20397400442015 @default.
• W2039740044 countsByYear W20397400442016 @default.
• W2039740044 countsByYear W20397400442017 @default.
• W2039740044 countsByYear W20397400442018 @default.
• W2039740044 countsByYear W20397400442019 @default.
• W2039740044 countsByYear W20397400442020 @default.
• W2039740044 countsByYear W20397400442021 @default.
• W2039740044 countsByYear W20397400442022 @default.
• W2039740044 countsByYear W20397400442023 @default.
• W2039740044 crossrefType "journal-article" @default.
• W2039740044 hasAuthorship W2039740044A5055914209 @default.
• W2039740044 hasAuthorship W2039740044A5069120338 @default.
• W2039740044 hasAuthorship W2039740044A5081428042 @default.
• W2039740044 hasAuthorship W2039740044A5084472288 @default.
• W2039740044 hasBestOaLocation W20397400441 @default.
• W2039740044 hasConcept C126322002 @default.
• W2039740044 hasConcept C137183658 @default.
• W2039740044 hasConcept C169760540 @default.
• W2039740044 hasConcept C170493617 @default.
• W2039740044 hasConcept C185592680 @default.
• W2039740044 hasConcept C200170125 @default.
• W2039740044 hasConcept C2779134260 @default.
• W2039740044 hasConcept C2779734285 @default.
• W2039740044 hasConcept C2780304432 @default.
• W2039740044 hasConcept C2780405171 @default.
• W2039740044 hasConcept C2911016594 @default.
• W2039740044 hasConcept C44208683 @default.
• W2039740044 hasConcept C513476851 @default.
• W2039740044 hasConcept C55493867 @default.
• W2039740044 hasConcept C71924100 @default.
• W2039740044 hasConcept C86803240 @default.
• W2039740044 hasConcept C98274493 @default.
• W2039740044 hasConceptScore W2039740044C126322002 @default.
• W2039740044 hasConceptScore W2039740044C137183658 @default.
• W2039740044 hasConceptScore W2039740044C169760540 @default.
• W2039740044 hasConceptScore W2039740044C170493617 @default.
• W2039740044 hasConceptScore W2039740044C185592680 @default.
• W2039740044 hasConceptScore W2039740044C200170125 @default.
• W2039740044 hasConceptScore W2039740044C2779134260 @default.
• W2039740044 hasConceptScore W2039740044C2779734285 @default.
• W2039740044 hasConceptScore W2039740044C2780304432 @default.
• W2039740044 hasConceptScore W2039740044C2780405171 @default.
• W2039740044 hasConceptScore W2039740044C2911016594 @default.
• W2039740044 hasConceptScore W2039740044C44208683 @default.
• W2039740044 hasConceptScore W2039740044C513476851 @default.
• W2039740044 hasConceptScore W2039740044C55493867 @default.
• W2039740044 hasConceptScore W2039740044C71924100 @default.
• W2039740044 hasConceptScore W2039740044C86803240 @default.
• W2039740044 hasConceptScore W2039740044C98274493 @default.
• W2039740044 hasIssue "1" @default.
• W2039740044 hasLocation W20397400441 @default.

• next