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- W2039748443 abstract "The protective effects of a series of pyridinium salts against soman poisoning were studied using female mice. From the most active compound, 130 nmoles/kg (i.m.) reduced the toxic effect of a LD95 of soman (s.c.) down to the 50 per cent mortality level. The compounds with protective activity in vivo were able to protect acetylcholinesterase (AChE) from soman in vitro. The protective efficiency was evaluated by comparing the rates of AChE inhibition in the absence and in the presence of 1 mM pyridinium salt. The most effective substances decreased the inhibition rate down to about 1100 of the unprotected value. Additionally, the influence of these compounds upon the acetylcholine hydrolysis by AChE was investigated. A striking correlation exists between the protective efficiencies in vitro and the competitive inhibition constants of the pyridinium salts." @default.
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- W2039748443 date "1976-09-01" @default.
- W2039748443 modified "2023-09-24" @default.
- W2039748443 title "Protective activity of pyridinium salts against soman poisoning in vivo and in vitro" @default.
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- W2039748443 doi "https://doi.org/10.1016/0006-2952(76)90049-6" @default.
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