FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2039759851> ?p ?o ?g. }

• W2039759851 abstract "Antigen receptor gene rearrangement studies are a sensitive means of determining lineage and clonality in lymphoproliferative disorders (LPDs) which remain difficult to classify after assessment of morphology and immunohistochemistry (IHC). This study investigates the utility of genotyping LPDs in a surgical pathology laboratory servicing a large teaching hospital. Ninety-eight specimens with detailed frozen (FS) and/or paraffin section IHC were studied, including 65 B-cell lymphomas, 14 T-cell lymphomas, 2 biopsies of T-zone dysplasia, one unclassifiable lymphoma, 8 Hodgkin's disease (HD) and 8 reactive nodes. Southern blotting (SB) was performed on tumor and control DNA cleaved with restriction enzymes EcoR1, Hind III and BamH1, using radiolabelled probes for the immunoglobulin heavy chain joining region, constant regions of kappa and lambda light chains, and the constant region of the T-cell receptor beta chain. All reactive nodes and those harbouring HD and DNA in the germline configuration, apart from JH rearrangement in one case each of HD and florid reactive hyperplasia. Of the non-Hodgkin's lymphomas (NHL), 17% did not reveal clonal rearrangements (11% B-NHL; 44% T-NHL). Most of the negative results could be explained by sampling error in partially involved nodes, highly polymorphous infiltrates where the neoplastic population may have been below the 1% threshold detectable by SB, and instances of anaplastic large cell lymphoma. After accounting for these cases, a 5% negative rate of genoclonality remained (3% B-NHL; 13% T-NHL). In the majority of NHL (95%), the diagnosis could be established on the basis of morphology and/or IHC alone.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2039759851 created "2016-06-24" @default.
• W2039759851 creator A5004134442 @default.
• W2039759851 creator A5005148628 @default.
• W2039759851 creator A5007469808 @default.
• W2039759851 creator A5017802048 @default.
• W2039759851 creator A5065704644 @default.
• W2039759851 date "1994-01-01" @default.
• W2039759851 modified "2023-09-27" @default.
• W2039759851 title "Southern blot analysis of lymphoproliferative disorders: use and limitations in routine surgical pathology" @default.
• W2039759851 cites W118434469 @default.
• W2039759851 cites W13386708 @default.
• W2039759851 cites W1504656568 @default.
• W2039759851 cites W1527303821 @default.
• W2039759851 cites W1534367492 @default.
• W2039759851 cites W1556356166 @default.
• W2039759851 cites W161786533 @default.
• W2039759851 cites W171001763 @default.
• W2039759851 cites W172662817 @default.
• W2039759851 cites W1743189389 @default.
• W2039759851 cites W1804396352 @default.
• W2039759851 cites W183477684 @default.
• W2039759851 cites W1896753380 @default.
• W2039759851 cites W1967591620 @default.
• W2039759851 cites W1970687636 @default.
• W2039759851 cites W1970945923 @default.
• W2039759851 cites W1980304797 @default.
• W2039759851 cites W1981530111 @default.
• W2039759851 cites W1984724325 @default.
• W2039759851 cites W1990952965 @default.
• W2039759851 cites W1996094622 @default.
• W2039759851 cites W2002192875 @default.
• W2039759851 cites W2008262149 @default.
• W2039759851 cites W2022341531 @default.
• W2039759851 cites W2025663531 @default.
• W2039759851 cites W2030609984 @default.
• W2039759851 cites W2035826293 @default.
• W2039759851 cites W2037702184 @default.
• W2039759851 cites W2047316056 @default.
• W2039759851 cites W2061736872 @default.
• W2039759851 cites W2063450941 @default.
• W2039759851 cites W2074241972 @default.
• W2039759851 cites W2119791173 @default.
• W2039759851 cites W2124313974 @default.
• W2039759851 cites W2129214379 @default.
• W2039759851 cites W2134798194 @default.
• W2039759851 cites W2144634347 @default.
• W2039759851 cites W2148354297 @default.
• W2039759851 cites W2152171889 @default.
• W2039759851 cites W2157273457 @default.
• W2039759851 cites W2158854612 @default.
• W2039759851 cites W2181087467 @default.
• W2039759851 cites W221387354 @default.
• W2039759851 cites W2261317284 @default.
• W2039759851 cites W2310750881 @default.
• W2039759851 cites W2316119724 @default.
• W2039759851 cites W2319793285 @default.
• W2039759851 cites W2322568421 @default.
• W2039759851 cites W2325652208 @default.
• W2039759851 cites W2328563034 @default.
• W2039759851 cites W2329361007 @default.
• W2039759851 cites W2333087288 @default.
• W2039759851 cites W2334098145 @default.
• W2039759851 cites W2335678588 @default.
• W2039759851 cites W2335942423 @default.
• W2039759851 cites W2337101530 @default.
• W2039759851 cites W2401471167 @default.
• W2039759851 cites W2408004710 @default.
• W2039759851 cites W2409713624 @default.
• W2039759851 cites W2413138011 @default.
• W2039759851 cites W2414818572 @default.
• W2039759851 cites W2415495468 @default.
• W2039759851 cites W2417246611 @default.
• W2039759851 cites W2419227780 @default.
• W2039759851 cites W2419411568 @default.
• W2039759851 cites W2426322407 @default.
• W2039759851 cites W293347905 @default.
• W2039759851 cites W3117197594 @default.
• W2039759851 cites W316369126 @default.
• W2039759851 cites W332444870 @default.
• W2039759851 cites W52259325 @default.
• W2039759851 cites W67186296 @default.
• W2039759851 cites W69174620 @default.
• W2039759851 cites W907265052 @default.
• W2039759851 cites W95845338 @default.
• W2039759851 cites W206583373 @default.
• W2039759851 cites W2127839813 @default.
• W2039759851 doi "https://doi.org/10.1080/00313029400169621" @default.
• W2039759851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7991281" @default.
• W2039759851 hasPublicationYear "1994" @default.
• W2039759851 type Work @default.
• W2039759851 sameAs 2039759851 @default.
• W2039759851 citedByCount "13" @default.
• W2039759851 crossrefType "journal-article" @default.
• W2039759851 hasAuthorship W2039759851A5004134442 @default.
• W2039759851 hasAuthorship W2039759851A5005148628 @default.
• W2039759851 hasAuthorship W2039759851A5007469808 @default.
• W2039759851 hasAuthorship W2039759851A5017802048 @default.
• W2039759851 hasAuthorship W2039759851A5065704644 @default.
• W2039759851 hasConcept C104317684 @default.

• next